Organothiophosphates have found widespread application as biologically active compounds and synthetic intermediates in medicinal chemistry. The first transition‐metal‐free one‐pot direct synthesis of heterocyclic phosphorothioates involving indole or imidazo[1,2‐a]pyridine derivatives, elemental sulfur, and P(O)H compounds is presented. The use of NaI or KI as a catalyst, tert‐butyl hydroperoxide as an oxidant, various indole and imidazo[1,2‐a]pyridine derivatives are tolerant in this transformation, affording the corresponding products in good to excellent yields. Moreover, this method can be easily adapted to large‐scale preparation. O,O‐Diethyl S‐(1‐phenyl‐1H‐indol‐3‐yl) phosphorothioate presents potent anti‐inflammatory activity in lipopolysaccharide (LPS)‐stimulated RAW264.7 cells in a dose‐dependent manner.

The catalytic C(sp 3 )−H functionalization is highly desirable yet challenging in organic synthesis. Incorporation of the SP(O)(OR) 2 group through C(sp 3 )−H functionalization remains unexplored. We herein report an unprecedented protocol for phosphorothiolation of primary and secondary C(sp 3 )−H via a multicomponent reaction with N-fluoro-substituted amides, elemental sulfur, and P(O)H compounds involving a sequence of amidyl radical generation, 1,5-HAT, and a Cu-catalyzed cross coupling of the resulting carbon radical with (RO) 2 P(O)SH (generated in situ).

The online service platform of chemical biology laboratory is a student-oriented and experimental teaching centered diversified innovation service platform, which is built with the help of modern information technology and WeChat public platform and WeChat group as the carrier. The platform includes three modules, namely, Alarm Bell, Laboratory Teaching and Platform Management, which are combined with safety education, assistant teaching and high-quality laboratory management. The construction of the platform conforms to the trend of laboratory information construction and the development needs of education and teaching reform, which is of great significance to laboratory teaching.