Nine new glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates,
pleionosides
M–U (1–9), and 12 known compounds
(10–21) were isolated from the pseudobulbs
of Pleione yunnanensis. Their structures and absolute
configurations were established through a combination of HRESIMS and
NMR data and supported by physical and chemical methods. Compounds 5, 6, 10, and 15 showed
significant in vitro hepatoprotective activity against d-galactosamine
(d-GalN)-induced toxicity in HL-7702 cells with increasing
cell viability by 27%, 22%, 19%, and 31% compared to the model group
(cf. bicyclol, 14%) at 10 μM, respectively. Compounds 4, 9, and 11 exhibited moderate
hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with
increasing cell viability by 9%, 16%, and 12% compared to the model
group (cf. bicyclol, 9%) at 10 μM, respectively.
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