BACKGROUND Diabetic mastopathy is a rare benign disease in clinical practice that mainly occurs in young and middle-aged women with type 1 diabetes. It has also been reported that this disease can be found in patients with type 2 diabetes and other autoimmune diseases, such as Hashimoto's thyroiditis, as well as in men. The pathogenesis of diabetic mastopathy is not yet clear, and it is easily confused with breast cancer due to their similar clinical manifestations and imaging features. CASE SUMMARY A 69-year-old female patient was admitted because of painless breast masses, with a history of type 2 diabetes. The imaging and physical examination suggested a high risk of breast cancer. Further histopathological analysis showed dense lymphocytes infiltrating around the lobules of the breast, and extensive fibrosis of the surrounding stroma. Finally, diabetic mastopathy was diagnosed. CONCLUSION The diagnosis of diabetic mastopathy in elderly patients with painless breast masses is difficult to distinguish from breast cancer, and its imaging manifestations are not specific.
Background Nonpuerperal mastitis (NPM) is a disease that presents with redness, swelling, heat, and pain during nonlactation and can often be confused with breast cancer. The etiology of NPM remains elusive; however, emerging clinical evidence suggests a potential involvement of lipid metabolism. Method Liquid chromatography‒mass spectrometry (LC/MS)-based untargeted lipidomics analysis combined with multivariate statistics was performed to investigate the NPM lipid change in breast tissue. Twenty patients with NPM and 10 controls were enrolled in this study. Results The results revealed significant differences in lipidomics profiles, and a total of 16 subclasses with 14,012 different lipids were identified in positive and negative ion modes. Among these lipids, triglycerides (TGs), phosphatidylethanolamines (PEs) and cardiolipins (CLs) were the top three lipid components between the NPM and control groups. Subsequently, a total of 35 lipids were subjected to screening as potential biomarkers, and the chosen lipid biomarkers exhibited enhanced discriminatory capability between the two groups. Furthermore, pathway analysis elucidated that the aforementioned alterations in lipids were primarily associated with the arachidonic acid metabolic pathway. The correlation between distinct lipid populations and clinical phenotypes was assessed through weighted gene coexpression network analysis (WGCNA). Conclusions This study demonstrates that untargeted lipidomics assays conducted on breast tissue samples from patients with NPM exhibit noteworthy alterations in lipidomes. The findings of this study highlight the substantial involvement of arachidonic acid metabolism in lipid metabolism within the context of NPM. Consequently, this study offers valuable insights that can contribute to a more comprehensive comprehension of NPM in subsequent investigations. Trial registration Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Number: 2019-702-57; Date: July 2019).
Background: Non-Puerperal Mastitis (NPM) is a type of disease that occurs during non-lactation accompanied by redness, swelling, heat and pain which is easily confused with breast cancer. The etiology of NPM is not yet clear. There is growing evidence from research showing that lipid metabolism may play an important role in NPM. This study aimed to use lipidomics to provide evidence for the etiology and potential therapeutic approaches for NPM. Method: Liquid chromatography mass spectrometry (LC/MS)-based untargeted lipidomics analysis combined with multivariate statistics were performed on investigating the NPM lipid change in breast tissue. Results: The results revealed significant differences in lipidomics profiles and a total of 16 subclasses with 14,012 different lipids were identified in positive and negative ion modes. Among these lipids, Triradylcglycerols (TAGs), Glycerophosphoethanolamines (PEs) and Glycerophosphoglycerophosphoglycerols (CLs)are top three lipid components between the NPM and control groups. Subsequently, 35 significantly different lipid metabolites were screened as potential biomarkers, such as 15(S)-Hydroxyeicosatrienoic acid, Lipoxin A4 (LXA4), Lipoxin B4 (LXB4) and LysoPC(16:0), and they showed good diagnostic performance. Detailed pathway analysis revealed that these dysregulated lipids are closely related to arachidonic acid metabolism, glycerophospholipid metabolism. Conclusions: This study showed that NPM patients' breast tissue exhibited altered lipid groups. In addition, the lipid metabolites screened and the pathways identified in this study may be potential targets for future studies of the pathogenesis of NPM. Trial registration: Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Number: 2019-702-57; Date: July 2019).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.