Representing features at multiple scales is of great importance for numerous vision tasks. Recent advances in backbone convolutional neural networks (CNNs) continually demonstrate stronger multi-scale representation ability, leading to consistent performance gains on a wide range of applications. However, most existing methods represent the multi-scale features in a layer-wise manner. In this paper, we propose a novel building block for CNNs, namely Res2Net, by constructing hierarchical residual-like connections within one single residual block. The Res2Net represents multi-scale features at a granular level and increases the range of receptive fields for each network layer. The proposed Res2Net block can be plugged into the state-of-the-art backbone CNN models, e.g., ResNet, ResNeXt, and DLA. We evaluate the Res2Net block on all these models and demonstrate consistent performance gains over baseline models on widely-used datasets, e.g., CIFAR-100 and ImageNet. Further ablation studies and experimental results on representative computer vision tasks, i.e., object detection, class activation mapping, and salient object detection, further verify the superiority of the Res2Net over the state-of-the-art baseline methods. The source code and trained models are available on https://mmcheng.net/res2net/.

Recently, the coronavirus disease 2019 (COVID-19) has caused a pandemic disease in over 200 countries, influencing billions of humans. To control the infection, identifying and separating the infected people is the most crucial step. The main diagnostic tool is the Reverse Transcription Polymerase Chain Reaction (RT-PCR) test. Still, the sensitivity of the RT-PCR test is not high enough to effectively prevent the pandemic. The chest CT scan test provides a valuable complementary tool to the RT-PCR test, and it can identify the patients in the early-stage with high sensitivity. However, the chest CT scan test is usually time-consuming, requiring about 21.5 minutes per case. This paper develops a novel Joint Classification and Segmentation (JCS) system to perform real-time and explainable COVID-19 chest CT diagnosis. To train our JCS system, we construct a large scale COVID-19 Classification and Segmentation (COVID-CS) dataset, with 144,167 chest CT images of 400 COVID-19 patients and 350 uninfected cases. 3,855 chest CT images of 200 patients are annotated with fine-grained pixel-level labels of opacifications, which are increased attenuation of the lung parenchyma. We also have annotated lesion counts, opacification areas, and locations and thus benefit various diagnosis aspects. Extensive experiments demonstrate that the proposed JCS diagnosis system is very efficient for COVID-19 classification and segmentation. It obtains an average sensitivity of 95.0% and a specificity of 93.0% on the classification test set, and 78.5% Dice score on the segmentation test set of our COVID-CS dataset. The COVID-CS dataset and code are available at https://github.com/yuhuan-wu/JCS.

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The accuracy of de novo protein structure prediction has been improved considerably in recent years, mostly due to the introduction of deep learning techniques. In this work, trRosettaX, an improved version of trRosetta for protein structure prediction is presented. The major improvement over trRosetta consists of two folds. The first is the application of a new multi‐scale network, i.e., Res2Net, for improved prediction of inter‐residue geometries, including distance and orientations. The second is an attention‐based module to exploit multiple homologous templates to increase the accuracy further. Compared with trRosetta, trRosettaX improves the contact precision by 6% and 8% on the free modeling targets of CASP13 and CASP14, respectively. A preliminary version of trRosettaX is ranked as one of the top server groups in CASP14's blind test. Additional benchmark test on 161 targets from CAMEO (between Jun and Sep 2020) shows that trRosettaX achieves an average TM‐score ≈0.8, outperforming the top groups in CAMEO. These data suggest the effectiveness of using the multi‐scale network and the benefit of incorporating homologous templates into the network. The trRosettaX algorithm is incorporated into the trRosetta server since Nov 2020. The web server, the training and inference codes are available at: https://yanglab.nankai.edu.cn/trRosetta/.

Current CNN-based solutions to salient object detection (SOD) mainly rely on the optimization of cross-entropy loss (CELoss). Then the quality of detected saliency maps is often evaluated in terms of F-measure. In this paper, we investigate an interesting issue: can we consistently use the F-measure formulation in both training and evaluation for SOD? By reformulating the standard F-measure we propose the relaxed F-measure which is differentiable w.r.t the posterior and can be easily appended to the back of CNNs as the loss function. Compared to the conventional cross-entropy loss of which the gradients decrease dramatically in the saturated area, our loss function, named FLoss, holds considerable gradients even when the activation approaches the target. Consequently, the FLoss can continuously force the network to produce polarized activations. Comprehensive benchmarks on several popular datasets show that FLoss outperforms the stateof-the-arts with a considerable margin. More specifically, due to the polarized predictions, our method is able to obtain high quality saliency maps without carefully tuning the optimal threshold, showing significant advantages in real world applications.

In natural images, the scales (thickness) of object skeletons may dramatically vary among objects and object parts, making object skeleton detection a challenging problem. We present a new convolutional neural network (CNN) architecture by introducing a novel hierarchical feature integration mechanism, named Hi-Fi, to address the skeleton detection problem. The proposed CNNbased approach has a powerful multi-scale feature integration ability that intrinsically captures highlevel semantics from deeper layers as well as lowlevel details from shallower layers. By hierarchically integrating different CNN feature levels with bidirectional guidance, our approach (1) enables mutual refinement across features of different levels, and (2) possesses the strong ability to capture both rich object context and high-resolution details. Experimental results show that our method significantly outperforms the state-of-the-art methods in terms of effectively fusing features from very different scales, as evidenced by a considerable performance improvement on several benchmarks.