Publication information Neuropharmacology, 63 (4): 750-760Publisher Elsevier Item record/more information http://hdl.handle.net/10197/3779 Publisher's statementThis is the author's version of a work that was accepted for publication in Neuropharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuropharmacology (VOL 63, ISSUE4, (2012) inhibitor, has been proposed to induce an adult phenotype with behavioural characteristics reminiscent of those observed in autism spectrum disorder (ASD). We have evaluated the face validity of this model in terms of social cognition deficits which are a major core symptom of ASD. We employed the social approach avoidance paradigm as a measure of social reciprocity, detection of biological motion that is crucial to social interactions, and spatial learning as an indicator of dorsal stream processing of social cognition and found each parameter to be significantly impaired in Wistar rats with prior in utero exposure to VPA. We found no significant change in the expression of neural cell adhesion molecule polysialylation state (NCAM PSA), a measure of construct validity, but a complete inability to increase its glycosylation state which is necessary to mount the neuroplastic response associated with effective spatial learning. Finally, in all cases, we found chronic HDAC inhibition, with either pan-specific or HDAC1-3 isoform-specific inhibitors, to significantly ameliorate deficits in both social cognition and its associated neuroplastic response. We conclude that in utero exposure to VPA provides a robust animal model for the social cognitive deficits of ASD and a potential screen for the development of novel therapeutics for this condition. 2 RUNNING TITLESocial deficit amelioration in rat autism model KEY WORDSHistone deacetylase; SAHA; MS-275; social interaction; biological motion; spatial learning; synaptic plasticity; NCAM PSA. ABBREVIATIONS

Many scholars have written on the conversion of Bhimrao Ambedkar from Hinduism to Buddhism, trying to explain it. In this paper, I argue that a hermeneutics of conversion is needed to understand what this transition means in the larger academic community. Through using the concept of the 'thematic site', a narrative trope that draws on the Lacanian idea of the 'point de capiton' (also known as the 'nodal point' or 'quilting point'), to investigate how the invisible is evoked in the visible of these scholarly accounts of Ambedkar's Buddhism, this paper argues that academic accounts of this conversion rearticulate colonial dichotomies of modern/traditional, mapping them onto the binary of West/East. That is, by tracing common academic representations of Ambedkar's conversion, this paper posits that there is an obfuscated relation that is articulated in the depiction of this event, a connection that invisibly connects Ambedkar's act to colonial constructions of knowledge.

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