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Deep Neural Networks (DNNs) has been dominating recent data mining related tasks with better performances. This article proposes a hybrid approach that exploits the unique predictive power of DNN and classical time series regression models, including Generalized Linear Model (GLM), Seasonal AutoRegressive Integrated Moving Average model (SARIMA) and AutoRegressive Integrated Moving Average with eXplanatory variable (ARIMAX) method, in forecasting time series in reality. For each selected time series regression model, three different hybrid strategies are designed in order to merge its results with DNNs, namely, Zhang's method, Khashei's method, and moving average filter-based method. The real seasonal time series data of patient arrival volume in a Hong Kong A&ED center was collected for the period July 1, 2009, through June 30, 2011 and is used for comparing the forecast accuracy of proposed hybrid strategies. The mean absolute percentage error (MAPE) is set as the metric and the result indicates that all hybrid models achieved higher accuracy than original single models. Among 3 hybrid strategies, generally, Khashei's method and moving average filter-based method achieve lower MAPE than Zhang's method. Furthermore, the predicted value is an important prerequisite of conducting the rostering and scheduling in A&ED center, either in the simulation-based approach or in the mathematical programming approach. INDEX TERMS Data mining, deep neural networks, hybrid approach, time series regression, data mining.

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