Abnormal UES function was noted in one-third of patients with LPR or GERD. However, there were no abnormalities on esophageal function testing specific for LPR.
Monthly report cards did not result in a change in PDR or APDRQ. In some environments, PDR can be used as a surrogate marker of ADR, despite endoscopist awareness that PDR is being measured.
Goals
Our aim was to study the prevalence of dysplasia and progression to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) in African Americans (AA) with Barrett’s esophagus (BE) and compare to Non-Hispanic White (NHW) controls.
Background
BE, a precursor of EAC, is a disease of predominantly white men and is uncommon in AA. The prevalence of dysplasia and progression to HGD and EAC in AA with BE is not clearly known.
Study
All AA or NHW patients with confirmed BE i.e. specialized intestinal metaplasia seen between 2002 and 2013 at our institution were included. Variables such as age, gender, medication use, body mass index, date of endoscopy, hiatal hernia size, BE length, and histological findings were noted. Progression to HGD/EAC was evaluated.
Results
Fifty two AA and 2394 NHW patients with BE were identified. There was a higher percentage of women in AA cohort (46.2%) than NHW cohort (24.9% p< 0.001). Nondysplastic BE was more prevalent in AA than in NHW (80.8% vs. 68.4%, p= 0.058). In the surveillance cohort of 20 AA and 991 NHW, no racial differences in progression to HGD/EAC were observed during a median follow-up of 43 months.
Conclusions
This study includes the largest number of AA with histologically confirmed BE reported so far. 46.2 % of AA with BE in our study were women. There was a trend towards higher prevalence of nondysplastic BE in AA compared to NHW.
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