Cytological study of body fluids has become integral part in both diagnostic and management of suspected malignant cases. The meticulous examination of body fluid for there cytomorphological properties throws light on the cause, presence of metastatic cells, typing of unknown cases, staging and prognosis of cancer.1) To study and evaluate current trends in cytological evaluation of body fluids for various pathological conditions in a tertiary care centre. 2) To analyse their frequency in relation to diagnosis.The present study is prospective type of analysis of 311 body fluids received in Department of pathology for duration of one year from Jan 2018 to Dec 2018 in our tertiary care centre. A total of 311 body fluid samples were analyzed in this study. Pleural fluid comprised of the major bulk of the study with 120 cases followed by peritoneal fluid with 100 cases. Non-malignant diagnosis was given in majority of the cases. Slight male preponderance was noted with male to female ration 1.37:1. Cytological analysis of body fluid is routine diagnostic investigation which offers definite aid to the treating physician. Preliminary body fluid analysis in resource limited setups still remains the most simple, convenient and cost effective technique in reaching to a particular diagnosis.
Introduction: Prostate cancer is the second common malignancy in men. Prostatic intraepithelial neoplasia (PIN) is the precursor lesion of prostatic carcinoma. Histopathological examination is necessary to diagnose PIN lesions. Objective: The aim of the study is to determine the incidence of Prostatic intraepithelial neoplasia and to analyse the usefulness of basal cell marker p63 expression in various lesions of prostate. Methods: This is a two-year prospective study of 65 transurethral resection specimens of prostate, carried out in the Department of pathology, Dr B R Ambedkar Medical College, Bangalore. mmunohistochemical marker p63 is used and its expression in various lesions was analysed. Results: Out of 65 cases studied, 4 were inflammatory lesions, 52 were benign prostatic hyperplasia (BPH) and 9 were malignant lesions. Low grade PIN was identified in 8(12.3%) cases of BPH. High grade PIN was seen in 9(13.8%) cases and tufting pattern was the commonest. HGPIN was predominantly associated with adenocarcinoma. p63 was expressed in all the benign glands in BPH and HGPIN. Malignant glands were negative for p63 expression.
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