Thiocyanation and formation of thioalkylated BODIPYs is a simple and reliable way for their chemical modification and photophysical tuning. ABSTRACTA high-yielding method for the direct thiocyanation of BODIPY dyes is described. In 1,3-dimethyl BODIPYs, the thiocyanato group adds at position 2, whereas the insertion occurs at position 5 in 3-amino BODIPYs. The transformation of the thiocyanato group enables the synthesis of thioalkylated BODIPYs. 2-Thioalkylated BODIPYs and 3-thiocyanato-5-piperidino BODIPYs exhibit interesting spectroscopical features. Hence, the described synthetic methodology can be used for the photophysical tuning of BODIPY dyes.

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The Front Cover shows efforts among Brazilian, American, and European researchers to combat neglected tropical diseases. New heterocyclic compounds based on imidazopyridine/pyrimidine and furopyridine cores originating from Brazil travel to the USA and Europe to be developed as anti‐infective agents against Trypanosomiases. By exploring the chemical diversity at eight different positions of the central core, we obtained various heterocyclic compounds having significant potential for anti‐trypanosomiases drug discovery. More information can be found in the Full Paper by Daniel G. Silva, Flavio S. Emery et al. Cover design by Daniel Gedder Silva.

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