An Efficient Three-Component Synthesis of 3-(1-Hydroxyalkyl)[1,2,4]triazolo[4,3-c]quinazolines S y n t h e s i s o f 3 -( 1 -H y d r o x y a l k y l ) [ 1 , 2 , 4 ] t r i a z o l o [ 4 , 3c ] q u i n a z o l i n e s
Polytungstozincate acid was prepared from sodium polytungstozincate and after formulation, Na 3 H 9 [WZn 3 (H 2 O) 2 (ZnW 9 O 34) 2 ], was used as an efficient catalyst for the synthesis of xanthene derivatives under solventfree conditions. The simple experimental procedure, short reaction times (40-120 min.), and excellent yields (81-94%) are the advantages of the present method.
A one-pot, four-component synthesis of 1,2,4-trisubstituted 1H-imidazoles is described. Heating a mixture of a 2-bromoacetophenone, an aldehyde, a primary amine, and ammonium acetate under solvent-free conditions affords functionalized imidazoles in good to excellent yields.
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