BACKGROUNDHydatid disease of the spleen should be kept as the differential diagnosis of all cystic masses in the spleen/abdomen. The anatomical relations of splenic hydatid cyst should be demonstrated before surgery because of varied presentations. Although the management must be individualised for each patient, a surgical resection is the best curative procedure. Postsurgical pharmacological treatment is necessary to ensure complete healing. Although hydatid disease affects any organ or soft tissue, it is most frequently found in liver (60-70%), lungs (30%), and rarely encountered in the kidney, spleen, bone, thyroid, breast and pancreas. Splenic hydatid disease is very rare with its occurrence less than 3% of the total incidence of Echinococcosis even in endemic areas. Berlot first described splenic hydatid cyst as an autopsy finding in 1790. (1) Primary infestation of the spleen usually takes place by the arterial route after the parasite has passed the two filters (hepatic and pulmonary). KEYWORDS Case ReportA 50-year-old female patient, housewife by occupation, presented to our general surgery clinic with a mass in the left upper abdomen since 10 years. There was left hypochondriac dull aching pain which did not shift or radiate. Lump as stated by the patient was progressive in nature, with history of decreased appetite and fullness of stomach. She had no history of jaundice, cough or respiratory distress, abdominal trauma, weight loss and her past medical history was unremarkable. Physical examination showed an asymmetric abdomen and a growing lump with smooth surface in left hypochondrium with palpable splenomegaly. Abdominal CT scan shows large homogenous cystic lesion in spleen with many septae, originating from the spleen. The cyst in the spleen appeared to fill the left quadrant of the abdominal cavity, most likely suggestive of hydatid cyst. There were no cysts in other Financial or Other, Competing Interest: None. Submission 20-10-2016, Peer Review 11-11-2016, Acceptance 19-11-2016, Published 24-11-2016. Corresponding Author: Dr. Saleem Tahir, Associate Professor, Department of Surgery, Era's Lucknow Medical College and Hospital, Lucknow-226003, Uttar Pradesh, India. E-mail: dr_tahir75@yahoo.com DOI: 10.14260/jemds/2016/1576 abdominal viscera. A radical splenic resection was done via left subcostal incision with removal of the hydatid cyst and section was sent for histopathology examination which came out to be a hydatid cyst. Specimen-Splenic HydatidCT Image