The emergence of the coronavirus disease 2019 (COVID-19) pandemic has made us appreciate how important it is to quickly develop treatments and save lives. The race to develop a vaccine for this novel coronavirus began as soon as the pandemic emerged. Time was the only limiting factor. From the first vaccine developed in 1796 against smallpox to the latest COVID-19 vaccine, there have been several vaccines that have reduced the burden of disease, with the associated mortality and morbidity. Over the years we have seen many new advancements in organism isolation, cell culture, whole-genome sequencing, and recombinant nuclear techniques. These techniques have greatly facilitated the development of vaccines. Each vaccine has its own development story and there is much wisdom to be gained from learning about breakthroughs in vaccine development.

As we move amidst the coronavirus disease 2019 (COVID-19) pandemic, we have witnessed tremendous distress, death, and turmoil of everyday life for more than one year now. However, they are not modern phenomena; deadly pandemics have happened throughout recorded history. Pandemics such as the plague, Spanish Flu, HIV, and Ebola caused deaths, destruction of political regimes, as well as financial and psychosocial burdens. However, they sometimes resulted in scientific discoveries. Understanding the mechanism of the emergence of these pandemics is crucial to control any spreading pandemic and prevent the emergence of a potential new one. Public health agencies need to work on improving the countries' pandemic preparedness to prevent any future pandemics. The review article aims to shed light on some of the deadliest pandemics throughout history, information of critical importance for clinicians and researchers.

Background The rapid emergence of the COVID-19 pandemic globally collapsed health care organizations worldwide. Incomplete knowledge of best practices, progression of disease, and its impact could result in fallible care. Data on symptoms and advancement of the SARS-CoV-2 virus leading to critical care admission have not been captured or communicated well between international organizations experiencing the same impact from the virus. This led to the expedited need for establishing international communication and data collection on the critical care patients admitted with COVID-19. Objective Developing a global registry to collect patient data in the critical care setting was imperative with the goal of analyzing and ameliorating outcomes. Methods A prospective, observational global registry database was put together to record extensive deidentified clinical information for patients hospitalized with COVID-19. Results Project management was crucial for prompt implementation of the registry for synchronization, improving efficiency, increasing innovation, and fostering global collaboration for valuable data collection. The Society of Critical Care Medicine Discovery VIRUS (Viral Infection and Respiratory Illness Universal Study): COVID-19 Registry would compile data for crucial longitudinal outcomes for disease, treatment, and research. The agile project management approach expedited establishing the registry in 15 days and submission of institutional review board agreement for 250 participating sites. There has been enrollment of sites every month with a total of 306 sites from 28 countries and 64,114 patients enrolled (as of June 7, 2021). Conclusions This protocol addresses project management lessons in a time of crises which can be a precept for rapid project management for a large-scale health care data registry. We aim to discuss the approach and methodology for establishing the registry, the challenges faced, and the factors contributing to successful outcomes. Trial Registration ClinicalTrials.gov NCT04323787; https://clinicaltrials.gov/ct2/show/NCT04323787

Objectives: Suggested therapeutic options for Multisystem Inflammatory Syndrome in Children (MIS-C) include intravenous immunoglobulins (IVIG) and steroids. Prior studies have shown the benefit of combination therapy with both agents on fever control or the resolution of organ dysfunction. The primary objective of this study was to analyze the impact of IVIG and steroids on hospital and ICU length of stay (LOS) in patients with MIS-C associated with Coronavirus Disease 2019 (COVID-19).

UNSTRUCTURED The COVID-19 pandemic emerged globally in a rapid and precipitous manner devastating healthcare organizations worldwide. The progression of the illness, the impact to the vulnerable and best care for the hospitalized patient, is undefined. Incomplete knowledge of best practices by frontline health care providers may result in error-prone care. Data on symptoms and advancement of the SARS-CoV-2 virus leading to critical care admission has not been captured or communicated well between international organizations experiencing the same impact from the virus. As the SARS-CoV-2 virus quickly reached every country, it was recognized that global communication and data collection on the critical care patients admitted with COVID-19 needed to be rapidly put in place. Developing a global registry to collect patient data and treatment in the critical care setting was of utmost priority with the goal to minimize preventable death, disability, and costly complications for patients with COVID-19. Project management around the prompt implementation of the registry is crucial. Valuable information could be lost daily without a format to record data and the opportunity to share significant findings. Putting the VIRUS: COVID-19 Registry in place could change patient outcomes by gaining insight to progression of symptoms and treatments worldwide. This article addresses project management lessons in a time of crises outlining the methodology used and is meant to be a useful tool for other organizations for rapid project management for a large-scale health care data registry.