To identify the main causes of neonatal morbidity and mortality a retrospective study was carried out at the Special Care Baby Unit (SCABU) of the Department of Paediatrics, Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM) for a period of 1 year from January to December 2005. A total of 361 neonates were included in this cohort. The ratio of male (200) and female (154) neonates was 1:0.7. Most of the babies (300) were born in this hospital. Major causes of morbidity were prematurity (60.7%), LBW ( 48.2%), jaundice (23.3%), severe perinatal asphyxia (10.8%), transient tachypnoea of newborn (10.8%), respiratory distress syndrome (6.4%) and sepsis (6.4%). Most deaths were associated with prematurity (71.1%), LBW (65.8%), intrauterine growth retardation (23.7%), respiratory distress syndrome (36.8%), severe perinatal asphyxia (18.4%) and sepsis/pneumonia (15.9%). Outcome of babies born in this hospital was better than those referred from other hospitals (p < 0.001).Ibrahim Med. Coll. J. 2007; 1(2): 1-4
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked human enzyme defect of red blood cells (RBCs). Individuals with this gene defect appear normal until exposed to oxidative stress which induces hemolysis. Consumption of certain foods such as fava beans, legumes; infection with bacteria or virus; and use of certain drugs such as primaquine, sulfa drugs etc. may result in lysis of RBCs in G6PD deficient individuals. The genetic defect that causes G6PD deficiency has been identified mostly as single base missense mutations. One hundred and sixty G6PD gene mutations, which lead to amino acid substitutions, have been described worldwide. The purpose of this study was to detect G6PD gene mutations in hospital-based settings in the local population of Dhaka city, Bangladesh. Qualitative fluorescent spot test and quantitative enzyme activity measurement using RANDOX G6PDH kit were performed for analysis of blood specimens and detection of G6PD-deficient participants. For G6PD-deficient samples, PCR was done with six sets of primers specific for G6PD gene. Automated Sanger sequencing of the PCR products was performed to identify the mutations in the gene. Based on fluorescence spot test and quantitative enzyme assay followed by G6PD gene sequencing, 12 specimens (11 males and one female) among 121 clinically suspected patient-specimens were found to be deficient, suggesting a frequency of 9.9% G6PD deficiency. Sequencing of the G6PD-deficient samples revealed c.C131G substitution (exon-3: Ala44Gly) in six samples, c.G487A substitution (exon-6:Gly163Ser) in five samples and c.G949A substitution (exon-9: Glu317Lys) of coding sequence in one sample. These mutations either affect NADP binding or disrupt protein structure. From the study it appears that Ala44Gly and Gly163Ser are the most common G6PD mutations in Dhaka, Bangladesh. This is the first study of G6PD mutations in Bangladesh.
Abstract:Objectives: Respiratory distress is one of the most common causes of admission in Neonatal intensive care unit (NICU). There are many causes of respiratory distress, among them, transient tachypnoea of newborn, respiratory distress syndrome and perinatal asphyxia are commonest causes. The aim of this study was to identify the etiology of respiratory distress in special care baby unit (SCABU) in BIRDEM General Hospital and to observe the immediate hospital outcome of these babies. Methods: A retrospective study was conducted in SCABU, BIRDEM. Data were collected from all patients files admitted in to SCABU during the period from January to December 2011. Results: A total of 562 patients were admitted, among them 192 cases were admitted due to respiratory distress (34.1%). There was male predominance (64.6%). Two third (65.6%) babies were inborn and majority (84.4%) were born by caesarian section and preterm babies were more (65.6%). The commonest causes of respiratory distress in our study were transient tachypnea
According to both scholars and society, Corporate Social Responsibility (CSR) plays a controversial role in terms of corporate management towards sustainability. The business has presently become an integrated with the society and takes in a complex form of global demand for sustainability management. Due to the globalization of business, it is difficult to form a common sustainability model for CSR while its approach could be an opportunity for achieving sustainability. Evidently, a strong connection is found between the CSR approach and achieving urban sustainability since a smart urbanization requires a well-planned industrialization process that could be accelerated by the proper application of CSR. However, the CSR concept has already been initiated and developed in Western developed countries. Nowadays, it is being widely practiced by the developing countries as well. The developing country Bangladesh takes CSR issues seriously. Therefore, the study seeks the sustainability prospects of CSR by considering sustainability challenges in the rapid development of the “Ready-made Garments (RMG)” industry and corporate sector in Bangladesh. Finally, this paper explores some strategic paths to initiate sustainable development by framing the conditions and challenges of CSR.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.