In the search for novel and bioactive molecules for drug discovery, marine-derived natural resources are becoming an important research area. Over 15 marine-derived secondary metabolites are currently in human clinical trials. Terrestrial fungi have produced many therapeutically significant molecules. However, the potential of marine fungi has only been investigated to a limited extent. This review article contains 103 marine-derived fungal metabolites and 77 references.

No abstract

We discuss numerical properties of continuous Galerkin-Petrov and discontinuous Galerkin time discretizations applied to the heat equation as a prototypical example for scalar parabolic partial differential equations. For the space discretization, we use biquadratic quadrilateral finite elements on general two-dimensional meshes. We discuss implementation aspects of the time discretization as well as efficient methods for solving the resulting block systems. Here, we compare a preconditioned BiCGStab solver as a Krylov space method with an adapted geometrical multigrid solver. Only the convergence of the multigrid method is almost independent of the mesh size and the time step leading to an efficient solution process. By means of numerical experiments we compare the different time discretizations with respect to accuracy and computational costs.

The present article is about the study of Darcy-Forchheimer flow of Maxwell nanofluid over a linear stretching surface. Effects like variable thermal conductivity, activation energy, nonlinear thermal radiation is also incorporated for the analysis of heat and mass transfer. The governing nonlinear partial differential equations (PDEs) with convective boundary conditions are first converted into the nonlinear ordinary differential equations (ODEs) with the help of similarity transformation, and then the resulting nonlinear ODEs are solved with the help of shooting method and MATLAB built-in bvp4c solver. The impact of different physical parameters like Brownian motion, thermophoresis parameter, Reynolds number, magnetic parameter, nonlinear radiative heat flux, Prandtl number, Lewis number, reaction rate constant, activation energy and Biot number on Nusselt number, velocity, temperature and concentration profile has been discussed. It is viewed that both thermophoresis parameter and activation energy parameter has ascending effect on the concentration profile.