Objective: To determine vitamin D deficiency (25-OH-D level <20 ng/ml) frequency among apparently healthy Afghan adolescents. Study Design: Cross-sectional analytical study. Place and Duration of Study: Pathology Department, French Medical Institute for Mothers and Children (FMIC) Kabul, from June to Sep 2016. Methodology: Adolescents who reported for analysis of vitamin D level in their sera were included. Age, gender, duration of sun exposure, area of exposed skin, types of living and eating lifestyles were documented. Vitamin D levels were measured by chemiluminescence method, using immunoassay autoanalysers. The participants were divided into five categories according to their serum vitamin D levels as sufficiency: >30-100 ng/ml; insufficiency: >20-29 ng/ml; deficiency: <20 ng/ml; severe deficiency: <10 ng/ml; and intoxication: >150 ng/ml. Participants who had vitamin D intoxication were excluded from the study. Results: Out of 308 cases for final analysis, 202 (65.6%) were females and 106 (34.4%) were males. Of all, 238 (77.3%) had a low level of vitamin D in their sera, whereas 70 (22.7%) had vitamin D sufficiency. Among those having hypovitaminosis D, 107 (45%) had severe deficiency, 81 (34%) had deficiency and 50 (21%) had vitamin D insufficiency. More pronounced lower levels were observed in females. Exposure to sun, use of a sun protector, vitamin D supplements, and vitamin D rich food intake, type of living, skin colour, and BMI of participants were seen as important factors linked to vitamin D levels. Conclusion: Hypovitaminosis D is prevailing among Afghan adolescents, more pronounced in girls. Wearing of traditional clothes, duration of sunlight, type of living and inadequate consumption of vitamin D rich foods are significant determinants of hypovitaminosis D.
Objective: Endocrinopathies are a commonly occurring entity, particularly those of the thyroid gland, however there is death of scientific literature from Afghanistan, a country with very limited health care facilities and resources. This is the first study aimed to describe the frequency of occurrence and factor associated with thyroid dysfunction in Afghan population. The aim of this study is to estimate the frequency and to identify factors associated with thyroid dysfunction among individuals coming to a tertiary care facility in Kabul, Afghanistan.Methods: A cross-sectional study was conducted from July to Sep 2018 at the Department of Clinical Pathology, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan. Blood samples were obtained, serum TSH levels were analyzed, and the patients were divided into three diagnostic categories according to their serum TSH concentrations: 1) Hypothyroidism 2) Hyperthyroidism 3) normal.Results: A total of 127 individuals were included in the final analysis. Majority study participants (77%) were females. A large number of the participants (92%) did not have family history of thyroid dysfunction. (74%) participants in the study had normal TSH levels classified as normal thyroid function, (14%) had lower TSH levels and (12%) higher TSH levels (Table 1) classified as hyper and hypothyroid respectively.Conclusion: The findings of the current study showed a high frequency of thyroid dysfunctions from a single center. Further large scale studies are needed to find out the prevalence and document this entity for better health outcomes in the country.
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