A novel, efficient one-pot approach for the synthesis of furopyrimidine and oxobenzofuran derivatives 4 by a multicomponent reaction of an isocyanide, an aldehyde, and a CH-acid compound in CH 2 Cl 2 is reported (Scheme 1 and Table). The reactions were completed after 20 h at room temperature. This method has the advantages of high yields, simple methodology, and easy workup.Introduction. -The synthetic routes to furopyrimidine and oxobenzofuran derivatives is not large, and only few procedures have been reported for the synthesis of furopyrimidines [1 -4], mostly relying on multi-step reactions giving low yields [1 -3]. These compounds are an important structural unit in natural products and are intermediates in drugs and organic synthesis [5] [6]. As part of our continuing interest in the development of new synthetic methods in heterocyclic chemistry and the recent interest in isocyanide-based multicomponent reactions [7 -10], we now describe an efficient synthesis of furopyrimidine and oxobenzofuran derivatives via the reaction of CH-acids with aldehydes and isocyanides in CH 2 Cl 2 at room temperature.
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