Introduction: Healthcare workers and professionals have the highest risk of transmission of novel coronavirus disease-2019 (COVID-19). The risks faced by healthcare professionals can vary according to their working conditions, knowledge, attitudes and behaviours. This study aimed to identify risk factors contributing to transmission among frontline healthcare providers in the pandemic period. Material and Method: The healthcare workers working at the school of medicine hospital and referred to the COVID-19 clinics by the filiation team following risky exposure between March 15, 2020 and December 31, 2020 were included in the study. sociodemographic features, use of protective equipment, unprotected contact data, and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Real-time reverse transcription-polymerase chain reaction (RT-PCR) test results recorded on the contact healthcare follow-up form of the participants were taken from the hospital records and analyzed retrospectively. Results: Of the healthcare workers included in the study, 790 (58%) were female, and 571 (42%) were male, with a mean age of 33,6±8,3 years. SARS-CoV2 PCR positivity was detected in 94 (6%) participants. According to the multivariate model results, the male gender was found as a risk factor in terms of transmission which increased the risk 1.633-fold [%95 Cl; (1,048-2,544), p=0,030], working in a laboratory unit increased the risk 2.89-fold [%95 Cl; (1,322-6,316), p=0,008], and contacting out of the hospital increased the risk 7.154-fold [%95 Cl; (4,085-12,529), p
Purpose: In this study, we evaluated healthcare-associated urinary tract infections caused by carbapenem-resistant Klebsiella pneumoniae. Materials and methods: The study included 134 patients, diagnosed with healthcare-associated urinary tract infection caused by carbapenem-resistant Klebsiella pneumoniae. Demographic features, initial clinical conditions, comorbidities, and Charlson’s comorbidity index of the patients were recorded. In addition, the MIC values of meropenem on the CR-Kp isolates, treatment regimens, clinical and microbiological responses to the treatment, as well as 14- and 28-day mortality rates of the patients, were reviewed. Results: The 14-day mortality rate was 34.3%, and the 28-day mortality rate was 42.5%. The mean age of the patients who died was significantly higher (p=0.03). Similarly, Charlson’s comorbidity index (p=0.03) and the qSOFA values (p=0.00) were significantly higher in the patients who died. The microbiological response rate was higher in the patients who survived (p=0.01) with no difference in bacteremia between the groups (p=0.29). It was found that combined antibiotherapy provided significantly better 14- and 28-day mortality rates compared to monotherapy in the group of patients with sepsis (p=0.00 and p=0.04, respectively). However, monotherapy and combination therapy in groups of patients without sepsis were insignificant (p=0.72 and p=0.36, respectively) Conclusion: Our study supports the use of combination therapy in patients with sepsis, and monotherapy with an in-vitro active agent may be used for patients without sepsis in the treatment of urinary tract infections caused by CR-KP.
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