Jurinea brevicaulis is a perennial herbaceous plant belonging to the Asteraceae family. J. brevicaulis is an endemic genus and grows Erzincan and Gümüşhane provinces in Turkey. Jurinea species are known to have anticancer, antibacterial, antifungal and antioxidant effects. In this article, it is aimed to evaluate the antioxidant capacity and cytotoxic effects of J. brevicaulis. Results indicate that, TPC values were between 41.7-537.5 GAE µg g-1 , FRAP values were between 109.52-1076.2 µM Trolox equivalent g-1 , CUPRAC values were between 231.4-3083.3 µM Trolox equivalent g-1 , IC50 values in DPPH determination were between 0.0102-3.4174 mg mL-1. The extracts caused cell death in a concentration-dependent manner in, IC50 values were calculated to be between 3.67-10.2 µg mL-1. In conclusion, the cytotoxic effects in cancerous cells and the high antioxidant capacity indicates that J. brevicaulis could be an important herb in developing new drugs.
Herbs are widely used in the treatment of diseases as colds, infections, and cancer. In this work, we evaluate Alcea calvertii, which is a perennial herbaceous plant belonging to the Malvaceae family. It spreads in Anatolia and Mediterranean region and has important uses in terms of ethnobotany. In this study, it was aimed to evaluate the cytotoxic potentials and to investigate the antioxidant activities of methanol, water, chloroform, and ethyl acetate extracts of the aerial parts of Alcea calvertii. For that, the antioxidant activity of Alcea calvertii was determined by four different methods [total phenolic content (TPC), ferric reducing antioxidant power (FRAP), copper reducing antioxidant capacity (CUPRAC) and 2,2-diphenylpicrylhydrazil (DPPH) radical scavenging activity. The cytotoxicity potential of extracts was assessed in the human lung cancer cell line (A549) by MTT assay. It was observed that the highest antioxidant activity was in the methanol extract and the antioxidant activity increased with increasing extract concentration; The TPC values were between 62.5 -414.6 GAE µg mL -1 , the FRAP values were between 115.7 -1321.4 µM Trolox equivalent g -1 , CUPRAC values were between 177.1 -1321.4 µM Trolox equivalent g -1 , and IC50 values in DPPH determination were between 0.0089 -3.5370 mg mL -1 . The extracts caused cytotoxicity in a concentration dependent manner, the IC50 values were calculated to be between 36.8 -62.64 µg mL -1 . It is concluded that Alcea calvertii could be an important herb in developing new drugs.
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