Coronavirus disease 2019 (COVID‐19) is a life‐threatening infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 pandemic causing morbidities and even deaths worldwide revealed that there is urgent need to find pharmacological agents or vaccines. Although there are a lot of agents under investigation, there is no approved agent for the prevention or treatment of the COVID‐19 yet. Treatment of patients remains mainly supportive as well as compassionate use of the agents under investigation. It is well established that excessive inflammatory and immune response as well as oxidative injury play a critical role in the pathogenesis of COVID‐19. In this review, we aimed to update knowledge about pathogenesis, clinical features and pharmacological treatment of COVID‐19 and review the potential beneficial effects of ancient antioxidant, anti‐inflammatory and immunomodulatory molecule melatonin for prevention and treatment of COVID‐19.
Purpose: We aimed to investigate the potential benefits of two doses of ivabradine against isoproterenol-induced myocardial damage in rats.
Methods: The rats were randomly divided into 4 groups: Control (n=8); Saline was administered, Isoproterenol (ISO) (n=12); 150 mg/kg ISO was administered for 2 days, ISO+Low-dose IVA (ISO+LIVA) (n=12); 1 mg/kg IVA was administered for 4 days in addition to ISO. ISO+High-dose IVA (ISO+HIVA) group (n=12): 10 mg/kg IVA was administered for 4 days in addition to ISO. Thereafter, hemodynamic, histopathological, and biochemical studies were performed.
Results: In the ISO+LIVA and ISO+HIVA groups, ISO-induced myocardial changes including increase in density of granulation tissue and degenerated cardiomyocyte were equally decreased. HR was mildly reduced and arterial blood pressures were slightly increased in the IVA-treated groups versus the ISO group. In the hearts of IVA-treated groups, malondialdehyde level was significantly reduced and Glutathione (GSH) level and catalase (CAT) activity were mildly increased compared to the ISO group. Elevation of GSH and CAT activity were more pronounced in ISO+HIVA group.
Conclusion: Our results indicate that both 1 mg/kg and 10 mg/kg doses of IVA were effective against heart damage induced by ISO via its negative chronotropic, anti-oxidant (dose dependent), anti-inflammatory and anti-degenerative properties.
Günümüzde, geleneksel ve tamamlayıcı tıp uygulamaları'nın (GETAT) ülkemizde ve dünya genelinde kullanılma sıklığı günden güne artmaktadır. Binlerce yıllık bir geçmişi olan kupa tedavisi, bu uygulamalardan biri olup hastalıkların profilaksisinde, farmakoterapiye yanıt alınamayan durumlarda alter-natif olarak veya kronik hastalıklarda farmakoterapiye yardımcı tedavi yöntemi olarak yer almaktadır. 1 Kupa tedavisinin dünyada ve ülkemizde koruyucu ve sağaltıcı sağlık sistemindeki yerinin yasal bir zemine oturtulması ve uygulamaya artan taleple birlikte, başta uygulayıcılar olmak üzere tüm sağlık
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.