Variants in transcriptional activator Gli Kruppel Family Member 3 (GLI3) have beenreported to be associated with several phenotypes including Greig cephalopolysyndactyly syndrome (MIM #175700), Pallister-Hall syndrome (PHS) (MIM #146510), postaxial polydactyly types A1 (PAPA1) and B (PAPB) (MIM #174200), and preaxial polydactyly type
In this new three-component reaction, maleate and fumarate derivatives produced from amine and dialkyl acetylenedicarboxylate in the presence of NCS or NBS at room temperature in good yields. Graphical abstract (CH 2 ) n NH 2 + OR 1
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