Introduction: Adenotonsillectomy is one of the common surgeries specifically performed in children. The major complication of this surgery is post-surgery pains. The present study compared the effect of acetaminophen and licorice-based traditional medicine for the alleviation pain in patients with adenotonsillectomy. Materials and Method: This single-blinded pilot clinical trial study was carried on 3–15-year-old patients who had undergone tonsillectomy. After the surgery patients of both groups received 10 mg/kg syrup of acetaminophen every six hours for 24 hours. In addition, in the patients of the experimental group, licorice lozenges (with doses of 1000 mg) were administered. Wong-Baker’s Faces Pain Scale was used to measure the level of pains. Results: A total of 40 patients were assessed. Friedman test demonstrated that the mean pain of the two groups showed significant reduction (p=0.001). Also, the Mann-Whitney-U test revealed that the mean pain severity in the licorice-receiving group in 6 (p=0.056), 12 (p=0.02) and 18 (p=0.006) hours after the surgery significantly decreased compared to that of the control group. Conclusion: The level of pain reduction after adenotonsillectomy in the licorice group was significantly higher than that in the control group.
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