Oxazepines, which were synthesized in literature by means a variety of methods, are of great importance in heterocyclic chemistry along with biology and pharmacology. In this work we tried to synthesize naphthoxazepines by using a number of Schiff bases, which were synthesized from 2-hydroxy-1-napthaldehyde and anilines. The obtained imines were reduced to amines, acylated with chloroacetyl chloride and cyclised to give naphthoxazepinones in an overall yield of 20-49%. The identifications of the isolated and purified compounds were determined by IR, UV, 1 H-NMR, 13 C-NMR, mass spectra and elemental analysis.
The influence of the styrene substituents in the inverse-electron Diels-Alder cycloaddition reaction is discussed. -(BILGIC*, S.; BILGIC, O.; BUEYUEKKIDAN, B.; GUENDUEZ, M.; J. Chem. Res. 2007, 2, 76-79; Dep. Chem., Fac. Arts Sci., Univ. Osmangazi, TR-26480 Eskisehir, Turk.; Eng.) -H. Haber
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.