Significance and Impact of the Study: Despite numerous efforts to clarify genotypic differences between antimicrobial resistant and susceptible Pseudomonas aeruginosa isolates, few studies addressed differences in metabolism of clinically important pathogens. To our knowledge, there has been no report on extracellular metabolite characterization of susceptible and resistant strains of P. aeruginosa. This study provides insights into a metabolic footprint of MDR and susceptible P. aeruginosa clinical isolates in mono-cultures.
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