Study Design-Correlation of locations of sacral insufficiency fractures are made to regions of stress depicted by finite element analysis derived from biomechanical models of patient activities.Objective-Sacral insufficiency fractures occur at consistent locations. It was postulated that sacral anatomy and sites of stress within the sacrum with routine activities in the setting of osteoporosis are foundations for determining patterns for the majority of sacral insufficiency fractures. Summary of Background Data-The predominant vertical components of sacral insufficiency fractures most frequently occur bilaterally through the alar regions of the sacrum which are the thickest and most robust appearing portions of the sacrum instead of subjacent to the central sacrum which bears the downward force of the spine.Methods-First, the exact locations of 108 cases of sacral insufficiency fractures were catalogued and compared to sacral anatomy. Second, different routine activities were simulated by pelvic models from CT scans of the pelvis and finite element analysis. Analyses were done to correlate sites of stress with activities within the sacrum and pelvis compared to patterns of sacral insufficiency fractures from 108 cases.Results-The sites of stress depicted by the finite element analysis walking model strongly correlated with identical locations for most sacral and pelvic insufficiency fractures. Consistent patterns of sacral insufficiency fractures emerged from the 108 cases and a biomechanical classification system is introduced. Additionally, alteration of walking mechanics and asymmetric sacral stress may alter the pattern of sacral insufficiency fractures noted with hip pathology (p=.002).Conclusions-Locations of sacral insufficiency fractures are nearly congruous with stress depicted by walking biomechanical models. Knowledge of stress locations with activities, cortical bone transmission of stress, usual fracture patterns, intensity of sacral stress with different activities, and modifiers of walking mechanics may aid medical management, interventional, or surgical efforts. NIH Public AccessAuthor Manuscript Spine (Phila Pa 1976). Author manuscript; available in PMC 2009 July 13. Published in final edited form as:Spine (Phila Pa 1976 Key Points• Identify the exact locations of sacral insufficiency fractures from large a consecutive series of cases by MRI and/or CT anatomical imaging methods.• Biomechanical model simulations to determine locations of stress within the sacrum with patient activities determined by finite element analysis.• Match clinical locations of sacral insufficiency fractures and sacral stress with activities as identified by the biomechanical models.• Sacral insufficiency fracture biomechanical classification system is introduced.• Knowledge of sacral stress locations with activities, cortical bone transmission of stress, usual sacral insufficiency fracture patterns, intensity of sacral stress with different activities, and modifiers of walking mechanics may aid medical, interve...

Object It is unclear how the biomechanics of dynamic posterior lumbar stabilization systems and traditional rigid pedicle screw-rod systems differ. This study examined the biomechanical response of a hinged-dynamic pedicle screw compared with a standard rigid screw used in a 1-level pedicle screw-rod construct. Methods Unembalmed human cadaveric L3–S1 segments were tested intact, after L4–5 discectomy, after rigid pedicle screw-rod fixation, and after dynamic pedicle screw-rod fixation. Specimens were loaded using pure moments to induce flexion, extension, lateral bending, and axial rotation while recording motion optoelectronically. Specimens were then loaded in physiological flexion-extension while applying 400 N of compression. Moment and force across instrumentation were recorded from pairs of strain gauges mounted on the interconnecting rods. Results The hinged-dynamic screws allowed an average of 160% greater range of motion during flexion, extension, lateral bending, and axial rotation than standard rigid screws (p < 0.03) but 30% less motion than normal. When using standard screws, bending moments and axial loads on the rods were greater than the bending moments and axial loads on the rods when using dynamic screws during most loading modes (p < 0.05). The axis of rotation shifted significantly posteriorly more than 10 mm from its normal position with both devices. Conclusions In a 1-level pedicle screw-rod construct, hinged-dynamic screws allowed a quantity of motion that was substantially closer to normal motion than that allowed by rigid pedicle screws. Both systems altered kinematics similarly. Less load was borne by the hinged screw construct, indicating that the hinged-dynamic screws allow less stress shielding than standard rigid screws.

The anchored spacer provided a similar biomechanical stability to that of the established anterior fusion technique using an anterior plate plus cage and has a potentially lower perioperative and postoperative morbidity. These results support progression to clinical trials using the cervical anchored spacer as a stand-alone implant.

Object An in vitro flexibility experiment was performed to compare the biomechanical stability of asymmetrical lumbar pedicle screw fixation (longer hardware attached ipsilaterally to a 1-sided lesion), short and long fixation, and fixation with and without interconnection to the involved vertebra. Methods Seven human cadaveric specimens (T12–S1) were studied intact; after simulated unilateral lesions were created at L2–3 and L3-4, the segments were stabilized by 1) L2–4 unilateral fixation (L-3 excluded), 2) L2–4 bilateral fixation (L-3 included contralaterally), 3) L2–5 unilateral fixation (L-3 excluded), 4) L2–5 fixation ipsilateral (L-3 excluded) and L2–4 fixation contralateral (L-3 included), 5) L2–5 bilateral fixation (L-3 included contralaterally), and 6) L2–5 bilateral fixation (L-3 excluded). The testing order varied among specimens. Angular range of motion (ROM) and lax zone were recorded optically while loading to 6.0 Nm was created with nonconstraining pure moments. Results Unilateral short fixation provided significantly worse stabilization than any other construct tested in all loading modes (p < 0.05, repeated-measures analysis of variance). There was a mean 56% reduction in ROM across the lesion after adding 1 additional level rostrally and caudally. Asymmetrical long/short stabilization provided similar stability to symmetrical long stabilization. Minimal additional stability was gained by including L-3 in the long bilateral fixation construct. Conclusions Unilateral fixation is inadequate for stabilizing a 2-level unilateral lesion. Bilateral fixation, whether symmetrical or asymmetrical, provides good stabilization for this injury. It is not important for stability to include the level of the lesion within the long construct contralaterally.

Laminoplasty leaves the spine in a significantly more stable condition than laminectomy. However, laminoplasty failed to relieve stenosis completely. In this study, stenosis was modeled as about 50% occlusion of the spinal canal. The degree of stenosis should be considered in clinical decisions of whether laminectomy or laminoplasty is more appropriate.

Angled screw insertion has been advocated to enhance fixation strength during posterior spine fixation. Stresses on a pedicle screw and surrounding vertebral bone with different screw angles were studied by finite element analysis during simulated multidirectional loading. Correlations between screw-specific vertebral geometric parameters and stresses were studied. Angulations in both the sagittal and axial planes affected stresses on the cortical and cancellous bones and the screw. Pedicle screws pointing laterally (vs. straight or medially) in the axial plane during superior screw angulation may be advantageous in terms of reducing the risk of both screw loosening and screw breakage.

Object The stability provided by 3 occipitoatlantal fixation techniques (occiput [Oc]–C1 transarticular screws, occipital keel screws rigidly interconnected with C-1 lateral mass screws, and suboccipital/sublaminar wired contoured rod) were compared. Methods Seven human cadaveric specimens received transarticular screws and 7 received occipital keel–C1 lateral mass screws. All specimens later underwent contoured rod fixation. All conditions were studied with and without placement of a structural graft wired between the skull base and C-1 lamina. Specimens were loaded quasistatically using pure moments to induce flexion, extension, lateral bending, and axial rotation while recording segmental motion optoelectronically. Flexibility was measured immediately postoperatively and after 10,000 cycles of fatigue. Results Application of Oc–C1 transarticular screws, with a wired graft, reduced the mean range of motion (ROM) to 3% of normal. Occipital keel–C1 lateral mass screws (also with graft) offered less stability than transarticular screws during extension and lateral bending (p < 0.02), reducing ROM to 17% of normal. The wired contoured rod reduced motion to 31% of normal, providing significantly less stability than either screw fixation technique. Fatigue increased motion in constructs fitted with transarticular screws, keel screws/lateral mass screw constructs, and contoured wired rods, by means of 19, 5, and 26%, respectively. In all constructs, adding a structural graft significantly improved stability, but the extent depended on the loading direction. Conclusions Assuming the presence of mild C1–2 instability, Oc–C1 transarticular screws and occipital keel–C1 lateral mass screws are approximately equivalent in performance for occipitoatlantal stabilization in promoting fusion. A posteriorly wired contoured rod is less likely to provide a good fusion environment because of less stabilizing potential and a greater likelihood of loosening with fatigue.

Object An experiment was performed to study the limits of the ability of screws designed to center themselves in the pedicle during insertion, and to study whether straight-ahead versus inward screw insertion trajectories differ in their resistance to pullout. Methods Forty-nine human cadaveric lumbar vertebrae were studied. Pedicle screws were inserted in trajectories starting 0°, 10°, 20°, or 30° from the optimal trajectory, either medially or laterally misdirected. The surgeon then inserted the screw with forward thrust but without resisting the screw's tendency to reorient its own trajectory during insertion. On the opposite pedicle, a control screw was inserted with the more standard inward-angled anatomical trajectory and insertion point. Cortical wall violation during insertion was recorded. Screws were then pulled out at a constant displacement rate while ultimate strength was recorded. Results Lateral misdirection as small as 10° was likely to lead to cortical wall violation (3 of 7 violations). Conversely, medial misdirection usually resulted in safe screw insertion (1 of 21 violations for 10°, 20°, or 30° medial misdirection). The resistance to pullout of screws inserted in a straight-ahead trajectory did not differ significantly from that of screws inserted along an inward trajectory (p = 0.68). Conclusions Self-tapping, self-drilling pedicle screws can redirect themselves to a much greater extent during medial than during lateral misdirection. The cortical wall is more likely to be violated laterally than medially. The strength of straight-ahead and inward trajectories was equivalent.