Event-related potential (ERP)-based P300 spellers are commonly used in the field of brain-computer interfaces as an alternative channel of communication for people with severe neuro-muscular diseases. This study introduces a novel P300 based brain-computer interface (BCI) stimulus paradigm using a random set presentation pattern and exploiting the effects of face familiarity. The effect of face familiarity is widely studied in the cognitive neurosciences and has recently been addressed for the purpose of BCI. In this study we compare P300-based BCI performances of a conventional row-column (RC)-based paradigm with our approach that combines a random set presentation paradigm with (non-) self-face stimuli. Our experimental results indicate stronger deflections of the ERPs in response to face stimuli, which are further enhanced when using the self-face images, and thereby improving P300-based spelling performance. This lead to a significant reduction of stimulus sequences required for correct character classification. These findings demonstrate a promising new approach for improving the speed and thus fluency of BCI-enhanced communication with the widely used P300-based BCI setup.
How brain dynamics change across conscious states, including reliable signatures of the transitions between unconsciousness and consciousness, remains unclear. In this work, we addressed the changes in functional brain networks during self-titrated midazolam sedation using high-density electroencephalography (EEG) in ten subjects. We were particularly interested in the underlying network alterations, identified with graph theory, associated with transitions between states of consciousness. The weighted Phase Lag Index (wPLI) was used as the connectivity estimator between two signals. Based on wPLI, we calculated network properties such as characteristic path length, clustering coefficient, and small-worldness for measuring the integration and segregation of the brain network. We found significant changes in power and wPLI at different levels of consciousness. During unconsciousness, wPLI over the parietal region was higher in the delta band (1-4Hz). The frontal-parietal interaction in the delta band was also stronger during the transition from consciousness to unconsciousness. There was the significant difference of wPLI over the frontal region between consciousness and unconsciousness in the sigma band (12-15Hz). The topological properties across conscious states were significantly changed in the delta band and sigma band. Our results showed parietal brain dynamics is associated with consciousness. Our data also suggest that reversible changes in delta power and connectivity underlie changes in conscious state.
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