Comparing new media to older media can help identify fundamental uses and perceived effects of communication technology. This study analyzes one soldier's milblog (military blog) and one Civil War soldier's letters and diaries to understand how milblogs compare to older forms of soldier correspondence. Despite the overt distinction in technical systems utilized, this analysis demonstrated that the communications through the milblog and letters/diaries share tremendous similarities. In composing their correspondence through these distinct media, each soldier maintained similar anxieties over technological affordances, perceptions of their audience, and motivations for corresponding. Though there were certainly differences in style and content, little that was done or accomplished via the milblog was without direct precedent in the Civil War letters and diaries.

Two subjects developed marked elevations in creatine kinase and other serum enzymes associated with mild myalgia during a randomized, double-blind, controlled Phase 1 clinical trial of an investigational live, attenuated vaccine against West Nile virus (ChimeriVax™-WN02). One subject had received ChimeriVax™-WN02 while the other subject was enrolled in an active control group and received licensed yellow fever 17D vaccine (YF-VAX ® ). Subsequently, the clinical trial was interrupted, and an investigation was begun to evaluate the enzyme abnormalities. As daily serum samples were collected for determination of quantitative viremia, it was possible to define the enzyme elevations with precision and to relate these elevations to physical activity of the subjects, symptoms, and virological and serological measurements. Evaluation of both subjects clearly showed that skeletal muscle injury, and not cardiac or hepatic dysfunction, was responsible for the biochemical abnormalities. This investigation also implicated strenuous exercise as the cause of the apparent muscle injury rather than the study vaccines. As a result of this experience, subjects engaged in future early-stage trials of these live, attenuated viral vaccines will be advised not to engage in contact sports or new or enhanced exercise regimens for which they are not trained or conditioned. The inclusion of placebo control arm (in lieu of or addition to an active vaccine control) will also be useful in differentiating causally related serum enzyme elevations.

Five term neonates diagnosed with immune thrombocytopenia were treated with 1 g/kg/day intravenous γ-globulin. Clinical and laboratory evidence of thrombocytopenia resolved completely in 4 of the 5 patients after a single dose. Only 1 patient received a second dose of the drug. This treatment protocol requires less γ-globulin than other protocols to safely reduce length of hospitalization.