No abstract

Predator urine, specifically fox urine, is a noxious but harmless olfactory stimulus. The results of previous studies have shown that fox urine is aversive to rats, and that rats react to fox urine in a similar manner as to other psychostressors. In the present study, the authors further investigated the use of fox urine as an aversive or stressful stimulus, specifically examining behavior change in open-field place-preference task. Three methods of presenting the fox urine were examined. Results indicated that fox urine decreased behavior, especially locomotion, during both fox-urine presentation and during a post-fox-urine recovery session. Data suggested that (a) there were fewer ambulatory episodes and less distance was traveled during the presentation of fox urine, regardless of presentation method, and (b) there were fewer vertical movements during fox-urine presentation when a fox-urine-laced cotton ball was set in the wood shavings than when it was placed on a bare floor or in a cup. The data suggested that fox urine may be an effective but nonharmful stimulus alternative for use in avoidance tasks.

No abstract

Alcohols Q 0230Towards the Development of Oxadiazinanones as Chiral Auxiliaries: Synthesis and Application of N3-Haloacetyloxadiazinanones. -The investigation is presented in extension of previous studies on the utilization of oxadiazinanones, derived from ephedrine and norephedrine, as chiral auxiliaries for asymmetric aldol addition reactions. -(HOOVER, T. R.; GROEPER, J. A.; PARROTT, R. W. I.; CHANDRASHEKAR, S. P.; FINEFIELD, J. M.; DOMINGUEZ, A.; HITCHCOCK*, S. R.; Tetrahedron: Asymmetry 17 (2006) 12, 1831-1841; Dep. Chem., Ill. State Univ., Normal, IL 61790, USA; Eng.) -Nuesgen 50-090

Changes in the sensitivity of response distributions to changes in reward distribution (reinforcer distribution sensitivity) were examined when rats were exposed to low and moderate doses of caffeine, ephedrine, and caffeine-ephedrine combinations. The data show significant decreases in sensitivity in response distributions to changes in reward schedule values during exposure to caffeine and ephedrine/caffeine combinations, whereas ephedrine alone resulted in overmatching comparable with baseline and NaCl conditions. Rats treated either with 3.0-mg/kg or 10.0-mg/kg doses of caffeine and all combinations of ephedrine at doses of 1.8 or 5.6 mg/kg with caffeine at 3.0 or 10.0 mg/kg showed reduced sensitivity in response distributions to differences in reinforcement schedule ratios. In contrast, when rats were exposed to ephedrine at 1.8 or 5.6 mg/kg, they maintained or increased the degree of overmatching. Although reinforcer distribution sensitivity was altered, drug exposure did not significantly affect the absolute rates of responding. Bias varied after exposure to caffeine, ephedrine, and their combinations, but not systematically. Finally, whereas the estimates of goodness of fit (r2) to the matching equation showed some decreases during drug exposure, these were neither statistically significant nor correlated with drug dose. These results suggest differential effects of ephedrine and caffeine on the sensitivity of response distributions to changes in reinforcement ratio distributions, with deleterious effects of caffeine and ephedrine/caffeine combinations.