Psoriatic arthritis (PsA) is a chronic inflammatory multisystemic disease. Limitations due to skin and joint involvement of the patients; can lead to negativie suffix in emotional state, social and physical activities. The aim of this study is to investigate the effects of parameters such as skin joint involvement and disease severity on factors such as fatigue, quality of life, depression, etc. in psoriasis and PsA patients. Thirty-four psoriasis and 48 PsA patients matched with each other in terms of age, sex, and other factors were included in the study. Disease severity was measured by Psoriasis Area Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Disease Activity in Psoriatic Arthritis (DAPSA) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores. In order to determine the depression status, quality of life and fatigue levels of the patients, respectively; Beck Depression Inventory (BDI), Health Assessment Questionnaire (HAQ) and Functional Assessment of Chronic Illness Therapy - fatigue scale (FACIT) scores were used. SPSS 17 for statistical evaluation (SPSS Inc. Released 2007. SPSS for Windows, Version 17.0. Chicago, SPSS Inc.) software package was used for analyses. Written informed consent was obtained from all patients who were enrolled to the study. PsA patients were found to have worse quality of life scores than psoriasis patients who were similar in terms of age, gender and other demographic characteristics. (0.22±0.36-0-0.48±0.52 p=0.017 respectively). There was a strong correlation between DAPSA scores and HAQ scores of the cases in the PsA group (r:0 ,615 p<0.05). Likewise, disease activity measured by DAPSA was found to have moderate correlation with FACIT score, and weak but statistically significant correlation with BDI score. (r: -0.578 p<0.05 and r:0.346 p<0.001, respectively). No correlation was found between NAPSI-PASI scores and HAQ, BDI - FACIT scores in both the psoriasis and PsA groups. Both psoriasis and PsA affect the quality of life, and our findings suggest that this effect is more pronounced in PsA patients. Our study supports that; the disease severity in PsA patients is related to depression, bad quality of life and fatigue level.
Erythema nodosum (EN) is the most common panniculitis which affects individuals from all ages. Etiologically most of the cases are idiopathic EN and infections rank the second. Its clinical presentation is sudden, hot erythematous nodules or plaques in legs, knees or ankles with a diameter ranging between 1 and 5 cm. In the majority of cases, healing is observed within two to eight weeks without any scar tissues. It may occasionally manifest itself as the first symptom of systemic diseases such as sarcoidosis, inflammatory bowel diseases, Behçet’s disease, and other rheumatological conditions. Therefore, EN cases must be carefully examined in terms of their etiologies. Herein, we report an interesting Brucella case presenting as a EN case consulted for rheumatological etiology investigation.
Purpose Vaccines are an identified cause of autoimmune/inflammatory syndrome which is termed as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In this research, we aimed to investigate the remarkable features of patients, whom we termed as ASIA syndrome, developing rheumatoid arthritis (RA) after BNT162b2 vaccination Methods Patients who were asymptomatic before BNT162b2 vaccination and developed chronic arthritis into three months after vaccination enrolled to the study. Demographic, laboratory, clinical, and treatment characteristics were reviewed retrospectively. Results We found 10 patients developing RA following BNT162b2 vaccination. The median age was 54.5 and six was of them were female. The median time between vaccination and onset of symptoms was seven days; seven patients had acute arthritis, and four had intermittent arthritis at the onset of the disease. Only three patients had a disease onset at small joints of the hands. All patients had radiological erosive changes on hand X-rays. Conclusion We reported a case series of ASIA syndrome for the first time who developed RA with erosive radiological features after the BNT162b2 vaccine. Acutely onset at atypical joints, intermittent course, and rapidly destructive changes on hand radiographs, were the spectacular features of our cases than classical RA. Vaccine-induced form may be an another subtype of RA but studies with larger sample sizes are needed.
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