We developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The T-PRF method is based on the hypothesis that titanium may be more effective in activating platelets than the silica activators used with glass tubes in Chouckroun's leukocyte- and platelet-rich fibrin (L-PRF) method. In this study, we aimed to define the structural characteristics of T-PRF and compare it with L-PRF. Blood samples were collected from 10 healthy male volunteers. The blood samples were drawn using a syringe. Nine milliliters was transferred to a dry glass tube, and 9 mL was transferred to a titanium tube. Half of each clot (i.e., the blood that was clotted using T-PRF or L-PRF) was processed with a scanning electron microscope (SEM). The other half of each clot was processed for fluorescence microscopy analysis and light microscopy analysis. The T-PRF samples seemed to have a highly organized network with continuous integrity compared to the other L-PRF samples. Histomorphometric analysis showed that T-PRF fibrin network covers larger area than L-PRF fibrin network; also fibrin seemed thicker in the T-PRF samples. This is the first human study to define T-PRF as an autogenous leukocyte- and platelet-rich fibrin product. The platelet activation by titanium seems to offer some high characteristics to T-PRF.
The purpose of this study was to compare the effect of ferrule with different heights on the stress distribution of dentin and the restoration-tooth complex, using the finite element stress analysis method. Three-dimensional finite element models simulating an endodontically treated maxillary central incisor restored with an all-ceramic crown were prepared. Three-dimensional models were varied in their ferrule height (NF: no ferrule, 1F: 1-mm ferrule, and 2F: 2-mm ferrule). A 300-N static occlusal load was applied to the palatal surface of the crown with a 135 degrees angle to the long axis of the tooth. In addition, two post and core materials with different elastic modulus were evaluated. The differences in stress transfer characteristics of the models were analyzed. Maximum stresses were concentrated on force application areas (32.6-32.8 MPa). The stress values observed with the use of a 2-mm ferrule (14.1/16.8 MPa) were lower than the no-ferrule design (14.9/17.1 MPa) for both the glass fiber-reinforced and zirconium oxide ceramic post systems, respectively. The stress values observed with zirconium oxide ceramic were higher than that of glass fiber-reinforced post system. The use of a ferrule in endodontically treated teeth restored with an all-ceramic post-and-core reduces the values of von Mises stresses on tooth-restoration complex. At rigid zirconium oxide ceramic post system, stress levels, both at dentin wall and within the post, were higher than that of fiber posts.
Regardless of restoration technique, fibre reinforcement of composite restorations decreased cusp movement in molar teeth with MOD and endodontic access cavities but did not affect fracture strength.
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