Rabbit muscle D-glyceraldehyde-3-phosphate dehydrogenase was shown to serve as a substrate for Ca*+/calmodulindependent protein kinase II with a K,,, of 0.33 PM and a V,,,,, of 2.63 pmol.min-i.rng-i at pH 7.5 and 30°C. In the absence of calmodulin, the V,,, was halved and K,,, unchanged. 0.99 mol of phosphate was incorporated per tetrameric molecule of D-glyceraldehyde-3-phosphate dehydrogenase under the experimental conditions employed.Phosphorylation; D-Glyceraldehyde-3-phosphate dehydrogenase; Ca2+/calmodulin-dependent protein kinase II
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