The use of andiroba in topical form may be associated with reduced intensity of OM. Seek therapeutic alternatives to minimize the pain and suffering that these side effects cause cancer patients is an important scientific step.

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Objectives This study aimed to assess whether the different biological behaviour between subtypes of unicystic ameloblastoma (UA) are related to the expression of proteins that modulate cell proliferation and apoptosis. Materials and methods Immunohistochemical study with a sample of 32 cases of UA, 11 cases of conventional ameloblastoma (CAM) and 10 dental follicles (DF) cases was performed. Cell proliferation was assessed using Ki-67 status and apoptosis by expression of Caspase-3. Positive cells were quantified in each sample and the difference among groups was compared. Results Mural UA (MUA) showed a higher immunostaining of Ki-67 (p < 0.05) and a lower immunostaining of Caspase-3 (p < 0.05) compared to luminal and intraluminal subtypes of UA (LIUA) and CAM. For both proteins, the LIUA and CAM groups showed no statistical difference. The neoplastic cells of the cystic capsule of the MUA showed a higher expression of Ki-67 protein (p < 0.0001) and a lower expression of Caspase-3 (p < 0.0001) compared to the lumen. DF showed lower Ki-67 and Caspase-3 immunostaining (p < 0.05) than neoplasms, except when comparing Caspase-3 expression between DF and MUA, as there was no statistical difference. Conclusions The higher immunoexpression of Ki-67 and lower of Caspase-3 in MUA, in the parenchyma cells inside the cystic capsule, suggests an association between the biological behaviour and the location of neoplastic cells in the tumour.

The oral mucositis is a mucosal alteration that usually arises from oncological treatments, such as chemotherapy, and it is characterized as an inflammatory process. The aim of this study is to demonstrate the chromatographic constitution of Andiroba oil, comparing and evaluating Andiroba oil and laser scarring efficiency in treatments of oral mucositis in hamsters. These animals were submitted to 5-Fluorouracil. A total of 122 animals were used, randomized and divided into the following groups: (a) positive control; (b) laser associated to andiroba oil; (c) laser; (d) andiroba oil; (e) negative control; (f) cyclophosphamide (genotoxicity control). The induction of oral mucositis occurred by the administration of intraperitoneal Fluorouracila (60 mg/kg) and trauma to the mucosa. The laser protocol was performed once a day and the andiroba oil applied 3 times a day (1,5 ml/day). The mucosae were photographed and removed for clinical and histopathological analysis on day 4, 8, 12 and 15. The analysis was based in OM severity, in specific scoring for the clinical and histopathological aspect. Toxicity was evaluated on day 15 using comet assay and it was performed by variant DNA damage parameters. The data were analysed using analysis of variance (ANOVA) Tukey post-test and Kruskal-Wallis Dunn post-test. The "andiroba oil" and "laser" groups presented better results when compared to the control groups and the treatment associations. The andiroba oil presented the best scarring results, even considering its efficiency proximity to the laser treatment. Andiroba and laser, separately, did not present genotoxicity, however their association evidences damage to DNA.