1997 stereochemistry stereochemistry (general, optical resolution) O 0030
-031Highly Stereoselective Aldol Reactions of Titanium Enolates from Ethyl α-Silyloxyalkyl Ketones. -The titanium-mediated aldol reaction of ketones (I) and aldehydes proceeds with high diastereoselectivities to produce preferentially the syn-syn adducts (III). In contrast to the reaction of the TBSprotected ketones (I), the aldol reaction of similar O-benzyl protected ketones gives lower diastereoselectivities. -(FIGUERAS, S.; MARTIN, R.; ROMEA, P.; URPI, F.; VILARRASA, J.; Tetrahedron Lett. 38 (1997) 9,
Ketones P 0200Stereoselective Titanium-Mediated Aldol Reactions of (S)-2-tert-Butyldimethylsilyloxy-3-pentanone. -The titanium-mediated aldol reaction of ketone (I) with achiral and chiral aldehydes provides 2,4-syn-4,5-syn adducts in high yields and diastereomeric ratios. Spectroscopic studies of the intermediates are carried out to propose a mechanism that accounts for the experimental results. -(NEBOT, J.; FIGUERAS, S.; ROMEA*, P.; URPI, F.; JI, Y.; Tetrahedron 62 (2006) 48, 11090-11099; Dep. Quim. Org., Univ. Barcelona, E-08028 Barcelona, Spain; Eng.) -Bartels 08-058
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