Alkylation of diaza-18-crown-6 by N-substituted phthalimides having a terminal halogen in the substituent, and subsequent product interaction with hydrazine hydrate and acid hydrolysis gave corresponding N,NЈ-disubstituted diaza-18-crown-6 compounds with terminal primary amino groups in the side chains. The reaction of these compounds with carbon disulfide or with appropriate bis[oligo(ethyleneoxy)]isothiocyanates afforded a series of novel cryptands with one or two thiourea units in one of the bridges.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.