No abstract

The initiation of HAART in asymptomatic patients with CD4 cell count > 350 x 10(6)/l significantly delayed clinical progression. However, the risk of severe clinical events with deferred therapy was low and must be counter balanced against the burden and toxicity of HAART.

Abacavir and amprenavir, a nucleoside reverse transcription inhibitor and a protease inhibitor, respectively, are new drugs used for the treatment of HIV. Methadone blood concentrations were measured in five addict patients receiving methadone maintenance therapy before and after introduction of abacavir plus amprenavir. The administration of these two drugs for a median period of 14 days resulted in a significant reduction (P = 0.043) of methadone concentration, with a median decrease to 35% of the original concentration (range 28-87%). Two patients reported on several occasions nausea in the morning before the intake of the daily methadone dose, which is compatible with withdrawal reaction to opioids. Because amprenavir is a cytochrome P4503A4 substrate and is involved in the metabolism of methadone, reduction of methadone concentrations could be explained by an induction of cytochrome P4503A4.

According to Buss and Schmitt's (1993) sexual strategies theory, mating strategies depend upon one's sex and whether they desire a short-term or long-term relationship. Men typically expend less reproductive effort than women and need only to ensure that they locate fertile mates, regardless of relationship type. Women tend to expend relatively more effort and seek long-term partners who are willing to provide resources, or they may choose mates with high genetic quality for a short-term relationship. Thus, the traits that men and women exhibit to prospective mates should be sex-specific. Our goal was to determine whether the photographs that accompany online personal advertisements reflect an awareness of sex-specific mating strategies, such that the sexes advertise distinct traits to potential mates. After conducting a pilot study, we collected 300 photographs from the online dating service "Lavalife" and examined them with respect to relationship type. We found women consistently advertise their reproductive fitness regardless of sought relationship type, directly supporting sexual strategies theory. However, men's photographs only provide indirect support for this theory, and there was minimal difference in men's portrayal of characteristics across relationship type.