No abstract

Activated protein C (APC) resistance is anActivated protein C (APC) is a key anticoagulant enzyme necessary for the correct inhibition of blood coagulation. APC aided by its cofactor protein S (PS) cleaves factors Villa and Va into inactive fragments on a phospholipid surface. The formation of a blood clot depends on the presence of a procoagulant phospholipid surface, on which many of the blood coagulation enzymes are assembled in effective complexes. Several cofactors have critical roles in these enzyme complexes. Two key components are the procoagulant cofactors, factor Va and factor Villa. Factor V (FV) and factor VIII (FVIII) are homologous proteins that accelerate the activation of prothrombin and factor X, respectively. The protein C system is a natural anticoagulant pathway that acts on the levels of factor Va and factor Villa to control clot propagation.

No abstract

No abstract