Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics'" simulation environment to predict the performance of the device. The microfluidic chip is fabricated out ofPDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proofof-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner.
Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics R simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed.
A substance that, following a reaction, becomes an intrinsic part of a chemical product. The material must be stable at room temperatures. During the CVD process, the precursor material is vaporized. The precursor gas is transported to the surface where it undergoes a chemical reaction to produce the desired thin film.
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