MicroRNAs are small RNAs with ability to attach to the large number of RNA that regulate gene expression on postranscriptional level via inhibition or degradation of specific mRNAs. MiRNAs in cells are the primary regulators of functions such as cell growth, differentiation, and apoptosis and considerably influence cell function. The expression levels of microRNAs change in human diseases, including cancer. These changes highlight their essential role in cancer pathogenesis. Ubiquitous irregular expression profiles of miRNAs have been detected in various human cancers using genome-wide identification techniques, which are emerging as novel diagnostic and prognostic cancer biomarkers of high specificity and sensitivity. The measurable miRNAs with enhanced stability in blood, tissues, and other body fluids provide a comprehensive source of miRNA-dependent biomarkers for human cancers. The leading role of miRNAs as potential biomarkers in human cancers is discussed in this article. In addition, the interests and difficulties of miRNAs as biomarkers have been explored.
Lung cancer is known as one of the most common cancers worldwide. Non-small cell lung cancer (NSCLC) is found in 85% of cases of lung cancer. In this study, we tried to identify genes that can be used to prevent cancer from progressing with inhibiting their expression by microRNAs. In fact, these gels can be targeted as a treatment. In this study, using the data obtained from the article, 37 genes were finally reached with the Venny 2.1 database. We then analyzed the genes involved in lung cancer, using databases such as DAVID, PANTHR, ENRICHER. Our work provides insight into PDGFRA, LAMC1, and MAP3K8 have critical roles in important pathways and biological process which can developed cancer such as; angiogenesis, integrin signalling pathway, and development process. for the first time, that mir-554 and mir-313 plays a critical role by inhibiting the proto- oncogene genes map3k8, PDGFR and lamc1.
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