Abstract-Wireless Sensor Networks (WSNs) enable the surveillance and reconnaissance of a particular area with low cost and less manpower. However, the biggest problem against the commercialization of the WSN is the limited lifetime of the battery-operated sensor node. Taking this problem into account, a mobile sink is deployed as a robot, vehicle or portable device to only activate the sensor nodes that are interesting to the sink and leaves other nodes deactivated for. This can considerably extend the lifetime of the sensor nodes compared to existing power management algorithm of using all nodes. However, in this environment, the mobility of the sink raises new issues of energy efficiency and connectivity in communications. To solve these issues, we propose a DRMOS (Dynamic Routing protocol for Mobile Sink) method that includes a designated wake-up-zone to make sensor nodes prepare for an incoming sink. The shape of the wake-up-zone is dynamically changing to reflect the past moving patterns of the sinks. Moreover, we present the extensive simulation results and recommend parameters for practical use of DRMOS from the simulation analysis.
PDE9 inhibitors have been studied to validate their potential to treat diabetes, neurodegenerative disorders, cardiovascular diseases, and erectile dysfunction. In this report, we have selected highly potent previously reported selective PDE9 inhibitors BAY73-6691R, BAY73-6691S, 28r, 28s, 3r, 3s, PF-0447943, PF-4181366, and 4r to elucidate the differences in their interaction patterns in the presence of different metal systems such as Zn/Mg, Mg/Mg, and Zn/Zn. The initial complexes were generated by molecular docking followed by molecular dynamics simulation for 100 ns in triplicate for each system to understand the interactions’ stability. The results were carefully analyzed, focusing on the ligands’ non-bonded interactions with PDE9 in different metal systems.
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