Purpose: Parenteral nutrition (PN) is a standard supportive care for pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) in Samsung Medical Center. The objective of this study was to identify the factors associated with the length of hospital stay (LOS) in pediatric HSCT patients administrating PN routinely. Methods: This was a retrospective study for 128 pediatric HSCT patients from Aug. 2008 to Dec. 2009. Demographics, nutrition status on the first report in the nutrition support team, calories and nutrients supplied, PN duration, LOS, PN-induced complications, and laboratory data were collected from electronic medical records. Multivariate analyses were conducted to identify factors associated with LOS. Results: The median age of registered patients was 70 months (range 6∼239 months). Twenty-three patients (18.0%) were malnourished moderately to severely when PN was started. Number of autologous HSCT was larger than allogeneic HSCT (87 vs 41). In children undergoing HSCT, LOS was significantly correlated with PN duration (P<0.001) and graft type (P<0.001). Especially, in autologous peripheral blood stem cell transplantation (PBSCT), malnourished patients at the beginning of PN were shown the tendency to increase LOS (P=0.024) and PN duration (P=0.043). Conclusion: In pediatric HSCT patients administrating PN routinely, LOS was associated with a graft type of HSCT and PN duration. Especially for autologous PBSCT patients, the nutrition status at the beginning of PN had the influence on LOS and PN duration. During the peri-HSCT period, careful nutrition monitoring can prevent malnutrition, decrease PN duration, and shorten LOS. (JKSPEN 2011;4(1):1-6) 서 론 조혈모세포이식(Hematopoietic stem cell transplantation, HSCT)은 혈액암, 유전 및 면역질환 등의 질병을 치료하기 위해 악성이거나 결함이 있는 골수를 교체하여 조혈과 면역 기능을 회복시키기 위해 시행되고, 1,2 고형암에서의 HSCT는 자가이식으로 고용량의 화학요법 시행 후 골수 재건을 위해 주로 시행된다. 2-7 HSCT 전에는 비정상 골수를 사멸하기 위해 투여하는 고 용량 항암제와 방사선 치료에 따른 부작용으로 심한 오심, 구토, 설사, 점막염 등의 빈도가 높고, 1,2 HSCT 후에는 입맛 의 변화나 간정맥폐색성 질환, 이식편대숙주질환과 같은 합병증으로 환자의 영양요구량은 증가하나 경구를 통한 적 절한 영양 공급은 어려워 1,2,8 영양학적 위험 상태에 빠지기 쉽다. 특히 소아암 환아는 영양상태가 불량할수록 면역기 능이 감소하며 기저질환으로 인한 예후가 좋지 않고 성장 이 저해된다. 9 일부 연구에서는 HSCT를 시행하는 시점에 정맥영양(Parenteral Nutrition, PN)을 공급하는 것이 생존율 을 향상시키고 질병의 재발에 걸리는 시간을 연장시킨다는 보고가 있으나, 10,11 American Society of Parenteral and Enteral Nutrition (ASPEN) 가이드라인에서는 PN으로 인한 감염이
This study aimed to investigate the current practices and characteristics of commercial Enteral/Parenteral nutrition (EN/PN) support in outpatients in a tertiary hospital. Methods : This retrospective study was examined outpatients who were prescribed commercial EN/PN at Samsung Medical Center in 2021. Demographics, disease classification, prescription departments, EN/PN calories, and home artificial nutrition (HAN) consultation were examined.Results : A total of 1,108 outpatients were enrolled, of which 1,009 were adults (91.1%).
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