BackgroundPrevious studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells and induces insulin secretion. However, there are no previous longitudinal studies in humans.MethodsWe analyzed the age- and sex-matched data of 240 normal weight and overweight Korean children from the Korean Metabolic disorders and Obesity Study in Elementary School children (K-MOSES), a prospective observational cohort study.ResultsAt baseline, ANGPTL8 concentrations were positively associated with triglycerides (TG) (r = 0.168, P = 0.010), whereas ANGPTL3 levels were associated with fasting insulin (r = 0.248, P < 0.001) and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.197, P = 0.002). Although both ANGPTL8 and ANGPTL3 levels did not differ between children with normal weight and children with overweight, ANGPTL8 levels were increased in males compared to females (341.2 [267.4–436.5] vs. 270.2 [213.9–378.8] pg/ml, P = 0.001). In particular, there was no significant inter-relationship between circulating ANGPTL8 and ANGPTL3 concentrations in Korean boys and girls (r = −0.073, P = 0.265). Multivariate analysis showed that baseline ANGPTL8 concentrations were independently associated with future changes of serum TG levels in Korean children after adjusting for confounding factors after a 3 year follow-up period (r = −0.165, P = 0.016).ConclusionsThis longitudinal study demonstrated for the first time that baseline ANGPTL8 levels were associated with baseline and future changes in TG levels in Korean children.

The Microenterprise Development Programs (MDPs) in the United States provide low-income women with business training and loans for their business start-up. This study investigates whether gender differences in social capital influence business start-up in order to find implications to improve female micro-entrepreneurs' business start-up. By analyzing the data from Panel Study of Entrepreneurial Dynamic (2001)(2002)(2003)(2004), this research finds that women are less likely to utilize bridging and linking social capital for their businesses and also are less likely to start up business compared to men. This study provides implications that U.S. MDPs need to develop gender-specific social capital interventions that support female participants' business start-up.

Aramid nanofibers (ANFs), typically produced by exfoliating aramid microfibers (Kevlar) in alkaline media, exhibit excellent mechanical properties and have therefore attracted increased attention as nanoscale building blocks. However, the preparation of aramid microfibers involves laborious and hazardous processes, which limits the industrial-scale use of ANFs. This work describes a facile and direct monomer-to-ANF synthesis via an as-synthesized intermediate low-molecular-weight poly­(p-phenylene terephthalamide) (PPTA) without requiring the environmentally destructive acids and high-order shearing processes. Under the employed conditions, PPTA immediately dissociates and self-assembles into ANFs within a time period of 15 h, which is much shorter than the time of 180 h (not including the Kevlar preparation time) required for the Kevlar-to-ANF conversion. Interestingly, the fabricated ANFs exhibit nanoscale dimensions and thermoplastic polyurethane (TPU) reinforcing effects similar to those of Kevlar-derived ANFs; i.e., a 1.5-fold TPU toughness improvement and a maximum ultimate tensile strength of 84 MPa are achieved at an ANF content of only 0.04 wt %. Remarkable reinforcement ability investigated by comprehensive analytical data comes from ANFs, which disturb ordered hydrogen bonding in hard segments and induce strain hardening along the elongation pathway. Thus, the developed approach paves the way to industrial-scale production of ANFs and related nanocomposites.

This study investigates the successful conditions and implementation strategies of local currency movements. Data for this study were collected using semi-structured interviews with six presidents or managers from five separate local currency agencies in the US, Canada, and the UK. Applying a grounded theory approach, this study finds that conditions associated with successful local currency movements include being located in less populated areas, in a small community with comparatively lower levels of household income, and in a community with prior experience with alternative economic movements. Successful implementation strategies include organizational strategies for seeking seed funding and merchant engagement, operational logistics, and communication and marketing skills. Additional leadership strategies comprise leaders’ previous experiences with community projects and their commitment to the community, employing a full-time coordinator, and engaging a group of leaders. Conclusions suggest practical implications to groups that may want to initiate local currency movements in their own communities.