Tetraazamacrocycles, like cyclam 1, are well-studied
polyamine ligands for metal ions that were first developed to model
biological processes. Despite being studied for nearly 60 years, the
development of chiral variants of 1 has been limited.
We report the synthesis of a chiral variant of 1, the
tetraazamacrocycle 2. Outlined herein are the synthesis
of 2, a preliminary study of its complexation with metal
ions, and the properties of the resulting metal complexes.
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