The laboratory findings identified influenza A virus as the primary causative viral agent for FRI in the Singapore military, in strong contrast to findings from temperate countries and countries where recruits are often vaccinated for influenza. Our results suggest that influenza vaccination should be considered as a requirement to reduce the incidence of influenza infections. This is the first report describing respiratory infections in a tropical military setting, in a developed country in Asia.
1. intake, which describes the time course of drug movement from the site of administration, e.g. mouth, to the site of measurement, e.g. blood. 2. disposition, which describes the time course of drug distribution and elimination from the site of measurement e.g. blood. Once absorbed into the body, drug compounds are distributed reversibly to various tissues of the body including the eliminating organs, such as liver and kidney, which results in a decrease in blood or plasma drug concentration. The decrease in the blood concentration could be due to reversible loss of drug from the blood to the tissues, defined as distribution, or the irreversible loss of drug from blood, defined as elimination. Disposition is therefore a combination distribution and elimination. 2. Distribution Once in the systemic circulation, the blood or plasma concentrations of a drug will depend on how extensively it is distributed to extravascular sites [2]. Drug concentration in whole blood represents the total concentrations of drug in the circulatory system. Plasma concentration do not account for drug molecules that are sequestered into red or white blood cells. In general,
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