Coordinated development of regional economy and ecological environment is one of the core issues of sustainable development practices. In this paper, the numerical parametric statistical method and geospatial analysis tools were used to analyze the spatial-temporal characteristics of coupling relationship between regional economy and ecological environment, the results show that:(1) The EKC of the regional economy and ecological environment is N-shaped, there exists co-integration relationship, but no granger causality between them. (2) The analysis of temporal characteristics shows that the index of economic curve increased relatively stable, since new century, it increases rapidly. The changes of the ecological environments index are relatively stable after it reaches a relative high level in 2005. (3) The spatial differences between regional economy and ecological environment show that all cities of Wanjiang City Belt have significant spatial variation characteristics. To be specific, the condition of regional economy and ecological environment in Hefei, Maanshan and Wuhu, etc. is better than Chizhou, Anqing and Xuancheng etc.
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