The possible role of L-arginine/nitric oxide (L-arginine/NO) pathway in the antinociceptive activity of thiamine (vitamin B 1 ) in p-benzoquinone-induced mouse writhing model was investigated. Thiamine (ED 50 , 0.11 mg/kg), L-arginine (50 mg/kg), N G -nitro-L-arginine methyl ester (L-NAME, 75 mg/kg) and morphine (ED 50 : 0.13 mg/kg) displayed antinociceptions following s.c. administrations (52.4 ± 5.5 %, 36.8 ± 7.7 %, 27.8 ± 11.1 %, 66.1 ± 3.5 %, respectively). However, methylene blue (MB, 40 mg/kg, s.c.) produced a nociception (−32.1 ± 9.9 %). Coadministration of B 1 with L-arginine did not significantly change L-arginine-induced antinociception (48.9 ± 3.7 %). Cotreatment of thiamine with L-NAME and MB significantly increased the L-NAME-induced antinociception (53.9 ± 3.9 %) and reversed the MB-induced nociception to antinociception (46.0 ± 4.2 %). L-Arginine and L-NAME-induced antinociceptions were significantly increased (55.9 ± 3.9 % and 61.1 ± 5.0 %, respectively) by morphine. MB-induced nociception significantly reversed to antinociception by the concomitant administration of morphine (41.6 ± 8.9 %). Thiamine and morphine coadministration displayed antinociception (46.0 ± 4.2 %). The present results suggest that thiamine could produce antinociception by the activation of guanylyl cyclase mediated by cyclic guanosine monophosphate (cGMP) that may trigger the possible involvement of central and/or peripheral L-arginine/ NO/cGMP pathway. Zusammenfassung Die Rolle der Aktivierung von Guanylylcyclase bei der Unterdrückung des chemisch induzierten Writhing bei Mäusen mittels ThiaminZiel dieser Studie war es, die mögliche Rolle von L-Arginin/Stickoxid (L-Arginin/NO) bei der antinociceptiven Aktivität von Thiamin (Vitamin B 1 ) am p-Benzochinon-induzierten Maus-Writhing-Modell zu untersuchen. Thiamin (ED 50 : 0.11 mg/kg), L-Arginin (50 mg/kg), N G -Nitro-L-argininmethylester (L-NAME, 75 mg/kg) und Morphin (ED 50 : 0.13 mg/kg) zeigten bei s.c. Verabreichung eine schmerzlindernde Wirkung (52.4 ± 5.5 %, 36.8 ± 7.7 %, 27.8 ± 11.1 %, 66.1 ±3.5 %, in dieser Reihenfolge). Methylenblau (MB, 40 mg/kg, s.c.) verursachte dagegen eine gesteigerte Schmerzempfindung (−32.1 ± 9.9 %). Die Verabreichung von Thiamin mit L-Arginin zusammen änderte die durch L-Arginin induzierte Schmerzempfindung (48.9 ± 3.7 %) nur unwesentlich. Die Eingabe von Thiamin mit L-NAME und MB zusammen erhöhte die durch L-NAME induzierte schmerzlindernde Wirkung (53.9 ± 3.9 %) signifikant und kehrte die durch MB induzierte Schmerzempfindung zur Schmerzlinderung um (46.0 ± 4.2 %). Gleichzeitige Gabe mit Morphin erhöhte deutlich den durch L-Arginin und L-
Patients with received anti-TNF-α therapy, are scanned with TST or Quantiferon. If latent tuberculosis infection are diagnosed, tuberculosis prophylaxis should be started pre-anti-TNF-α therapy at least one month and INH chemoprophylaxis should be completed on 9 months or RIF should be completed on 4 months. Serum liver enzymes and bilirubin measurements monthly; follow-up physical examination and chest radiography should be performed for 3 months.
Objective: Sleep fragmentation occurs proportionally with the severity of disease in Obstructive sleep apnea syndrome (OSAS) patients. Deep sleep decreases in patients. Depression incidence increases depending on poor sleep, cognitive impairment, and the character and personality changes. Our aim in this study, we examined the relationship between oxygen desaturation and the Beck depression index (BDI) in patients with OSAS. Materials and Methods: Two hundred nineteen patients with polysomnography (PSG) and BDI records were included in this crosssectional and retrospective study. The age range of patients was in 18-78. In OSAS group, 57 patients were mild [respiratory disturbance index (RDI): 5-15)]; 54 patients were moderate (RDI: 15.1-30); 52 patients were severe (RDI: >30). Fifty-six patients (RDI <5) were control group. Exclusion criterions were major depression, other psychiatric disorders and to receive depression treatment when PSG recordings were made. The results of Beck depression inventory were evaluated according to the criterion that BDI: 0-13 normal; BDI: 14-19 mild depression, BDI: 20-28 moderate depression, BDI: >29 severe depression. Results: The results of Beck Depression Index were observed as normal or mild depression at whole study population. The oxygen desaturation in patients with OSAS was increasing due to the severity of disease. But, between BDI and the oxygen desaturation there was no correlation in OSAS patients as compared with the control group. Conclusion: Depression is common due to chronic insomnia and especially fragmentation of sleep in OSAS. However, in our study, we observed the patients with normal or mild depressive symptoms. Between BDI and the oxygen desaturation there was no correlation. Hypoxemia was not provoked depression, however was suggested in the mood changes that due to insufficient sleep and the reduction of sleep depth. Keywords: Obstructive sleep apnea syndrome, Beck depression index, oxygen sesaturation index Amaç: Obstrüktif uyku apne sendromlu (OUAS) hastalarda, hastalık ağırlığı ile orantılı olarak uyku fragmantasyonu gerçekleşir. Hastalarda, derin uyku azalır. Yetersiz uyku, bilişsel bozukluklar, karakter ve kişilik değişikliklerine bağlı depresyon görülme oranı artar. Bu çalışmada amacımız, OUAS'lı hastalarda oksijen desatürasyon miktarı artışı ile Beck depresyon indeksi (BDİ) arasında ilişkiyi incelemekti. Gereç ve Yöntem: Laboratuvarımıza başvuran ve polisomnografi (PSG) yapılan iki yüz on dokuz hasta için kayıtlardan, retrospektif ve kesitsel olarak yararlanılması hedeflendi. PSG ile OUAS tanısı alan 18-78 yaş aralığındaki hastalardan, hastalık ağırlığı hafif olan elli yedi, orta olan elli dört ve ağır olan elli iki hastanın, PSG'de Solunum bozukluğu indeksi <5 olan elli altı hastanın da kontrol grubu olarak alınması planlandı. Çalışmaya dahil edilen hastalarda, müraacatları esnasında rutin olarak değerlendirilen BDİ bakılması planlandı. Depresyon ve diğer majör psikiyatrik hastalık tanılı hastalar ve PSG kayıtları yapıldığı zaman depresyon tedavisi...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.