Objectives: There is an increasing evidence of immune mediated mechanism in the etiopathogenesis of Otitis Media prime middle ear inflammation prime. The aim of the present study was to determine the expression of important circulatory regulators of immunotolerance as biomarkers. Materials and Methods In this cross sectional study, a total of 44 OM patients and 37 controls were included. Blood plasma level of HB-EGF, IL-10, TNF-alpha, IFN-gamma, PD-L1 and VEGF-A were quantified using Human Magnetic Luminex assay. Results The study showed statistical significant differences in the levels of VEGF-A between OM patients with and without tympanic membrane perforations (p<0.05). Moreover, we found comparatively higher level of PD-L1 in OM patients than controls. However, the level of growth factor HB-EGF, is significantly higher in controls than the cases (p<0.05). There was also a correlation between the levels of HB-EGF and VEGF-A and the severity of the disease condition. Conclusions Role of inflammatory mediators and cytokines like PD-L1, IFNgamma, TNFalpha and IL-10in OM patients as a biomarkers are very minimal. VEFG-A have a significant role in the pathogenesis of OM.Further studies are required for better understanding of the role of these immunosuppressive mediators in the eitopathogenesis of OM.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.