This randomized, controlled trial shows that acetaminophen reduces kidney dysfunction and risk of developing acute kidney injury, particularly in severe malaria patients who present with high plasma hemoglobin, supporting the hypothesis that acetaminophen inhibits cell-free hemoglobin-mediated renal tubular oxidative damage.
Background: Bangladesh, A country with scintillating beauty of nature burdened with a dense population. Along with infectious diseases, tropical diseases are also prevalent here with a higher trend of non- communicable diseases as a result of industrialization. Practicing and prescribing as a doctor is a quite challenging profession here particularly when to deal with vast rural populations in a low resource facility. Medical education system is well developed in Bangladesh which follows traditional curriculum of teaching learning. Students are not accustomed with problem-based learning as it does not exist in curriculum. In order to confront with diverse disease pattern and overloaded population in this arduous backdrop of Bangladesh, problem- based learning can be a very effective tool for preparing medical students as an efficient, self- directed and insightful prescriber. This study was a primary step to introduce problem- based learning (PBL) to medical students of Bangladesh to evaluate the effectiveness of PBL in context of Bangladesh. Methods: Around 117 students of 4th year from 6 different medical colleges were randomly assigned for this study. Among them, half of the students attended PBL session for three days on a topic of Pharmacology and other students participated traditional lecture class. Following classes, odds ratio of performance was determined. MCQ, SAQ and total scores of assessment were compared. Comparison of scores was also done between male and female students of PBL group. Results: PBL students performed better than the LBL students. Odds ratio of their assessment performance was 252.08; with 95% confidence interval and lower range 53.89 and upper range 1179.28. The odds ratio showed strong association between PBL and student performance in Bangladesh context. Mean of total score was 30.7 ± 4.3 in PBL group and 17.2 ± 4.8 in LBL group. Total score was significantly higher (p= 0.000) in PBL group. Mean SAQ score in PBL and LBL group was 17.2 ± 2.2 and 5.3 ± 1.9 respectively which was extremely significant (p= 0.000). MCQ score mean was 13.4 ± 3.4 in PBL group versus 11.8 ± 3.7 in LBL group which was significantly higher in PBL group (p= 0.02). Among PBL group, total score and SAQ score was significantly higher in female students over male students. Conclusion: Significant findings of this study revealed PBL as an effective tool in Bangladesh context. Thereby, it is recommended from this study to take approaches for further study and initiative to incorporate PBL in curriculum as well. Bangladesh Journal of Medical Education Vol.12(1) 2021: 22-31
Background : The objective of the present study was to evaluate the sub-acute toxic effects of ethanol extract of fenugreek seeds on kidney tissues of albino rats. Materials and methods: The present study was conducted on 30 albino rats divided into Group A, B, C, D and R. Group A (Control group) was treated with distilled water. Group B, Group C and Group D were treated orally with ethanol extract of fenugreek seeds at a dose of 1.25 gm/kg/day, 2.5 gm/kg/day and 5 gm/kg/day respectively for 90 consecutive days. Group R (Recovery group) was treated with seed extract of 5 gm/kg/day for 90 days followed by no treatment for next 28 days to observe any toxic effect if present in highest dose whether reversible or not. On 91st day all the animals of Group A, Group B, Group C and Group D were sacrificed and Group R was sacrificed on 119th day. Blood sample was collected from all the rats by cardiac puncture before sacrifice for measurement of biochemical and hematological parameters, and kidneys were collected for histopathological examination after sacrifice. Results: Upto 2.5 gm /kg/day dose level, all parameters of all experimental groups were statistically not significant when compared with control group. At 5 gm/kg/ day dose level the seeds extract produced statistically significant change in biochemical parameters such as serum creatinine and blood urea. In gross microscopic examination of kidney, at the highest dose level showed the sign of cell injury like cellular swelling, hemorrhage, inflammatory cells infiltration, necrosis etc. Interestingly, these biochemical and microscopic findings at the highest dose level were absent in recovery group. Conclusion: Finally, the study revealed that ethanol extract of fenugreek seeds was non toxic up to 2.5 gm/kg/day dose level and produce renal toxicity at 5 gm/kg/day dose level in sub acute toxicity test. So, if needed to use in higher therapeutic dose the toxicity profile of seeds extract must be re-evaluated. Chatt Maa Shi Hosp Med Coll J; Vol.18 (1); Jan 2019; Page 36-43
Chenopodium album Linn (Called Bathua in Bengali) is a plant which has a long history of uses in liver disorders in this subcontinent. This study was done to evaluate the hepatoprotective effects of ethanol extract of this plant on paracetamol induced hepatotoxicity in albino rats. The total experiments were designed as follows (I) Experiment (part I):-Induction of hepatotoxicity by single administration of paracetamol at a dose of 2 gm/kg body weight. (2) Experiment (part II) : Effects of ethanol extract of Chenopodium album Linn. on paracetamol induced hepatotoxicity in albino rats. The biochemical reports suggested that acute administration of paracetamol produced significant hepatotoxicity in experimental rats which was evidenced by significant increase in Serum Bilirubin, Serum Alanine Aminotransferase (ALT) Serum Aspartate Aminotransferase (AST) Serum Alkaline Phosphatese (ALP) level, decrease in serum albumin and serum total protein level. When rats were treated with extracts of C. album plant in paracetamol induced hepatotoxic albino rats, the results showed marked reduction in serum bilirubin, serum ALT, serum AST and serum ALP level and increase of serum albumin level but not sigificant increase of total protein as compared with paracetamol treated group. The results of the present study revealed that ethanol extract of Chenopodium album Linn. whole plant has got protective effects against paracetamol induced hepatotoxicity. Further study is needed to find out the curative effect and to isolate the active principle and to explore out the exact hepatoprotective mechanism of this plant extract.
Introduction: Painful exposures have the potential for deleterious consequences upon neonates. Although Opioids and NSAIDs play important role in postoperative pain control, those are associated with side effects. We have studied use of ketorolac as postoperative analgesic in Bangladeshi neonates. Methods: This prospective study was undertaken in the
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