Triple therapy is independently associated with a higher survival rate among patients with CAPS.

The objective of this study was to determine seroprevalence and identify risk factors associated with Toxocara canis infection. A clinical and epidemiological questionnaire and body mass index were used to assess the risk factors associated with human toxocariasis in 108 children with an age range of 2–16 years. Antibodies against Toxocara canis were detected using an ELISA test kit. Chi-square analysis and odds ratio (OR) were used to identify risk factors associated with Toxocara canis seropositivity. The prevalence of antibodies against Toxocara canis was greater (P = 0.02) in males than females (28.84% and 16.07%, resp.). Chi-square analysis and odds ratio revealed just one variable with P < 0.05, and OR > 1.0 was associated with seropositivity: the possession of dogs under one year old (OR = 1.78). Although not significant, the OR values suggest that other factors may be epidemiologically important for Toxocara presence such as not washing hands before meals, malnutrition, obesity, and use of public parks. Children in the age group >12 and <16 years old had higher seroprevalence to Toxocara canis (17.59%) than the >2 and <11 years old age group (4.62%). Toxocariosis infection needs to be prevented by pet deworming and hygienic measures after contact with dogs.

Toxocarosis is entheroparasitosis frequently present in dogs and cats which is maintained in the environment by the infestation and reinfestation of the hosts, by the ingestion of food and soil contaminated with larvated eggs, ingestion of larvae in tissue of paratenic larvae (rats and birds), by transplacentary migration of a female dog to their fetus, transmammary passage in milk, or ingestion of larvae or faeces from puppets infested (1) . Human subjects, mainly children, are infested by the accidental ingestion of embryonated eggs from the soil contaminated by the dogs, and even when most of the seropositive patients may be asymptomatic, the parasite may cause fever, hepatomegaly, esplenomegaly, hypergammaglobulinaemia, eosinophilia, adenopathies and disorders of central nervous system, myocardium, eyes, skin, respiratory symptoms and even as a fatal disease (2,3) . The aim of the present study was to analyse the relationship of nutritional status in Toxocara canis infested children and adolescents in the State of Mexico. A study comprising 108 patients between 2 and 16 years of age, both male and female (56 men and 52 women) from the State of Mexico was carried out. Their T. canis antibodies' levels were measured by means of an ELISA test. The BMI was evaluated in order to assess nutritional status. We used a chi-square and risk test (OR) in order to compare the difference between groups and the relationship between nutritional status and parasitosis. A regression analysis was also conducted between antibody presence and BMI. According to standards established by the World Health Organization (2004), 49 % of the participants had a normal BMI; 30 % showed low weight, first-and second-degree malnutrition; and the remaining 21 % showed overweight and first-degree obesity. Twenty-five individuals (fourteen males and eleven females) between 2 and 14 years of age presented antibodies for T. canis larva migrans. From these parasitised children and teenagers 48 % showed a normal BMI; 36 % showed underweight and first-and second-degree malnutrition; and 16 % showed overweight and first-degree obesity. Nutritional status was not associated with toxocariasis serology; risk factors (RF) are low, indicating that other factors may be more important in the presence of the disease. The lack of a relation between BMI and parasitosis was confirmed by the null correlation between seropositivity and BMI (r = 0.08). It can be concluded that nutritional status is not associated with seropositivity for Toxocara. Parasitic infections are highly prevalent in populations of developing countries, affecting mostly those groups with higher nutritional deficit; therefore it is intended to extend the current study with the purpose of relating toxocariasis pathophysiology with the nutritional status of patients.