Sarcoidosis is a multisystem granulomatous disease which is observed worldwide. Sarcoidosis is one of the common causes of ocular inflammation. The choroidal vascularity index, defined as the ratio of the luminal area to the total choroidal area, is used as one of the biomarkers for assessing the choroid vascular state. We aimed to compare choroidal vascularity index and thickness measurements between sarcoidosis patients and healthy controls.Thirty-one patients with sarcoidosis and 31 age-gender matched healthy participants were recruited in this cross-sectional and comparative study. Choroidal vascularity index was defined as the ratio of luminal area to total choroidal area after binarization on optical coherence tomography images. Anterior segment examinations included central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and iridocorneal angle. Spectral-domain optical coherence tomography was used to measure peripapillary retinal nerve fiber layer thickness, choroidal thickness, and retinal vessel caliber.The mean choroidal vascularity index value was 61.6% in sarcoidosis patients and 62.4% in healthy controls (P = .69). The choroidal vascularity index and thickness were significantly correlated in both sarcoidosis (r = 0.41, P = .026) and control groups (r = 0.51, P = .006). Both the sarcoidosis and control groups had similar measured values for central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and iridocorneal angle (P > .05). Mean retinal nerve fiber layer, retinal arteriole and venule caliber, and choroidal thickness measurements did not differ significantly between the groups (P > .05).Sarcoidosis patients in quiescent period have similar choroidal vascularity index and thickness with healthy controls.
Bu çalışmada, koruyucu katkı maddesi kullanmaksızın hindi etinden üretilen sosislere 118 °C'de 50 dakika sterilizasyon uygulanarak, 4 aylık depolama süreci boyunca mikrobiyolojik bozulmanın önlenmesi ve genel kalitenin korunması amaçlanmıştır. Çalışmada konserve sosis üretiminde kullanılan çiğ hindi etinin başlangıç bakteri yükü 4.33 log kob/g olarak tespit edilmiştir. Isıl işlem sonrasında raf ömrü boyunca sosis örneklerinde mikrobiyolojik bir gelişmenin tespit edilmemiş olması, ürüne uygulanan ısıl işlemin etkin bir şekilde sterilizasyon sağlamış olduğunu göstermiştir. Oksidasyon derecesinin belirlendiği tiyobarbitürik asit (TBA) analizinde ise, hindi sosislerinde istatistiksel olarak fark görülmemiştir (P >0.05). Bu çalışma, sıcak dolum ve etkin bir ısıl işlem ile üretilen hindi sosislerinin koruyucu katkı kullanılmaksızın raf ömrü süresince sağlıklı bir şekilde korunabileceğini göstermiştir.
SIGNIFICANCE The mechanisms of sighting ocular dominance, which is particularly important in monovision therapies and sports vision, are not fully understood yet. Whether the macula affects ocular dominance or ocular dominance affects the macula is also a subject of interest. PURPOSE The aim of this study was to investigate the relationship of sighting ocular dominance with macular photostress test time and middle macular layer thickness. METHODS One-hundred eyes of 50 healthy adult volunteers were included in this cross-sectional study. Sighting eye dominance was decided by a hole-in-the-card test. The macular photostress test was performed by exposing the eye to the ophthalmoscope light for 10 seconds and measuring the time taken to return to visual acuity within one row of pre-light exposure acuity. The spectral-domain optical coherence tomography examinations were performed to measure thickness of middle macular layers (i.e., outer nuclear, outer plexiform, inner nuclear, and inner plexiform). Refractive error and intraocular pressure (IOP) measurements were also recorded. RESULTS The comparison of dominant and nondominant eyes in the aspect of refractive error, IOP, and macular photostress test time did not show statistically significant differences (P > .05). The thicknesses of macular outer nuclear, outer plexiform, inner nuclear, and inner plexiform layers were similar in the dominant and nondominant eyes (P > .05). In addition, macular photostress time was not statistically significantly correlated with the thickness of middle macular layers (P > .05). CONCLUSIONS The thickness of middle macular layers and macular photostress recovery time are similar in dominant and nondominant eyes.
BackgroundSince pediatric uveitis is generally asymptomatic, the diagnosis and treatment may be mostly delayed. Severe complications and visual loss may be observed even at the initial visit. Pediatric uveitis is tend to be chronic, persistent, recurrent, and the management may be complex (1).ObjectivesThe aim of this study is to report epidemiology, etiology, clinical features, management and the outcomes of non infectious pediatric uveitis at a tertiary pediatric rheumatology center in Turkey.MethodsThe clinical records of the patients with non infectious uveitis who were followed up by department of pediatric rheumatology and ophtalmology were reviewed, from January 2013 to June 2018, retrospectively. The inclusion criteria were as follows being age ≤ 16 years, following up at least 6 months in both the ophtalmology and pediatric rheumatology clinics. Uveitis was categorized anatomically according to the Standardization of Uveitis Nomenclature criteria (2).ResultsOf 37 patients (67 eyes), 45,9% were female. Mean age of onset was 8, 5 ± 4, 4 years (1,6 - 15,6), mean follow-up was 60 ± 42 months (6 - 191). The general features of uveitis were anterior, idiopathic and bilateral in this study similar to literature (Table 1).The most common systemic diseases associated with uveitis were juvenile idiopathic arthritis (JIA).Two patients improved with local medications, while the remaining 35 patients required systemic treatments such as short-time (oral/iv) corticosteroids (CS) in 94.5% of them, methotrexate (MTX) in 86.4%, azathioprine (AZA) in 5.4%, adalimumab (ADA) in 67.5%, tocilizumab (TCB) in 2.7%. In 26.1% of patients receiving ADA who did not respond to standard dose of ADA, we had to shorten the dosage intervals of ADA from every 2 weeks to every week. At least 1 ocular complication was observed in 83.7% of the patients, such as cataract, glaucoma, band keratopathy, synechiae, macular edema and retinal detachment. Four (10.8%) patients had moderate visual loss and 6 (16.2%) patients severe visual loss (3). The prevalence of surgery in our study was 18.9% for cataract and glaucoma treatment.ConclusionDiagnosis and management of uveitis in childhood is complicated. Despite the new medication options, the advancements in diagnosis and surgical techniques, the complications are still high. Usage of shorter dose interval of ADA may be an alternative to control of the disease in patients with unresponsive to standard dosage of ADA. However large-scale clinical trials are required to assess the efficacy and safety of this treatment.References[1] Tugal-Tutkun I. Pediatric uveitis. J Ophthalmic Vis Res 2011; 6: 259-269.[2] Jabs DA, Nussenblatt RB, Rosenbaum JT, et al. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 2005; 140:509–16.[3] World Health Organisation. Report of WHO/IAPB scientific meeting, Hyderabad, India 13-47. Childhood Blindness Prevention. WHO/PBL/87. 1999.Disclosure of InterestsNone declaredAbstract AB1072 Table 1Clinica...
Objectives: In this study, we aimed to describe the demographic and clinical findings of children with uveitis at a tertiary pediatric rheumatology and ophthalmology center. Materials and Methods:A retrospective cross-sectional study was conducted with 46 patients who were diagnosed with uveitis before the age of 16 years and were followed regularly for at least 6 months between January 2013 and June 2019. Demographic data, uveitis characteristics, underlying diseases, systemic treatment modalities, drug side effects, complications, and surgical intervention were evaluated. Results: Eighty-three eyes of 46 patients were included in the study. The mean age at diagnosis of uveitis was 9.2±4.5 (1.6-15.6) years, and the mean uveitis follow-up period was 54±41 (6-191) months. Twenty-one patients (45.7%) had uveitis associated with rheumatologic diseases. Juvenile idiopathic arthritis was the most common disease (23.9%). Visual acuity was categorized as moderately impaired in 6 eyes (7.2%), severely impaired in 4 eyes (4.8%), and blindness in 1 eye (1.2%). Methotrexate (87%) was the most frequently used systemic immunosuppressive agent in treatment. Adalimumab (73.9%) was added to treatment in resistant cases. Thirtyfive patients (76.1%) had complications in at least 1 eye secondary to uveitis or uveitis treatment. Posterior synechiae (11 eyes, 13.2%) was the most common complication during treatment. Conclusion:In order to preserve visual acuity, pediatric uveitis should be recognized early and especially persistent/chronic cases should be started on effective systemic treatment immediately.
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