Azinomycins A and B, isolated from the culture broth of Streptomyces griseofuscus S 42227, were examined for antitumor activities against P388 leukemia, P815 mastocytoma, B-16 melanoma, Ehrlich carcinoma, Lewis lung carcinoma and Meth A fibrosarcoma. Azinomycin B was markedly effective against the intraperitoneally inoculated tumors such as P388 leukemia, B-16 melanoma and Ehrlich carcinoma. The intraperitoneal administration of azinomycin B showed 57% survivors for 45 days and 193 % ILS against P388 leukemia. For Ehrlich carcinoma, azinomycin B gave 161 % ILS and 63% survivors for 45 days, but solid tumors such as Lewis lung carcinoma and Meth A fibrosarcoma were not susceptible to repeated injection of this substance. AzinomycinA was somewhatless effective than azinomycin B for the tumor systems tested.
A strain of Streptomyces griseofuscus S42227 (FERM P-8443) was found to produce new antitumor antibiotics, called azinomycins A and B. The molecular formulas of azinomycins A and B were determined as C30H33N3O10 and C31H33N3O11, respectively. They were active against Gram-positive bacteria, Gram-negative bacteria and L5178Y cells in tissue culture.
The new piericidin group antibiotics, glucopiericidins A and B were isolated from the culture broth of Streptomyces pactum S48727 (FERMP-8117) as co-metabolite of piericidin Ai.The structures of glucopiericidins A and B were determined as piericidin Al9 10-O-fi-Dglucoside and piericidin Al9 3'-0-D-glucoside on the basis of their spectral and chemical properties , respectively.Glucopiericidins were more potent in inhibiting antibody formation than piericidin Ai in vitro. In addition, these substances showedbetter antimicrobial activities than piericidin AÂ cute toxicities of these substances in mice were lower than that of piericidin Ax. This indicates that D-glucose in glucopiericidin molecules is important in modulating their physiological activities.In the course of a screening for physiologically active substances, a strain of actinomycetes, S48727, was shown to produce new piericidin glucosides, glucopiericidins A and B in addition to the known antibiotic piericidin A^K They showed antimicrobial activity and in vitro inhibitory activity against antibody formation. This paper reports the taxomony of the producing organism and the fermentation, the isolation, structures and biological properties of glucopiericidins A and B.Taxonomy
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