Fig. 1. Genomics Data Visualizations Using Gosling. A wide range of genomics visualizations in the wild can be expressed by Gosling and rendered by Gosling.js, a declarative grammar and its JavaScript toolkit for scalable and interactive visualizations for genome-mapped data.

We present a systematic review on three comparative layouts-juxtaposition, superposition, and explicit-encoding-which are information visualization (InfoVis) layouts designed to support comparison tasks. For the last decade, these layouts have served as fundamental idioms in designing many visualization systems. However, we found that the layouts have been used with inconsistent terms and confusion, and the lessons from previous studies are fragmented. The goal of our research is to distill the results from previous studies into a consistent and reusable framework. We review 127 research papers, including 15 papers with quantitative user studies, which employed comparative layouts. We first alleviate the ambiguous boundaries in the design space of comparative layouts by suggesting lucid terminology (e.g., chart-wise and item-wise juxtaposition). We then identify the diverse aspects of comparative layouts, such as the advantages and concerns of using each layout in the real-world scenarios and researchers' approaches to overcome the concerns. Building our knowledge on top of the initial insights gained from the Gleicher et al.'s survey [19], we elaborate on relevant empirical evidence that we distilled from our survey (e.g., the actual effectiveness of the layouts in different study settings) and identify novel facets that the original work did not cover (e.g., the familiarity of the layouts to people). Finally, we show the consistent and contradictory results on the performance of comparative layouts and offer practical implications for using the layouts by suggesting trade-offs and seven actionable guidelines.

As large-screen smartphones are trending, they bring a new set of challenges such as acquiring unreachable screen targets using one hand. To understand users' touch behavior on large mobile touchscreens, we conducted an empirical experiment to discover their usage patterns of tilting devices toward their thumbs to touch screen regions. Exploiting this natural tilting behavior, we designed three novel mobile interaction techniques: TiltSlide, TiltReduction, and TiltCursor. We conducted a controlled experiment to compare our methods with other existing methods, and then evaluated them in real mobile phone scenarios such as sending an e-mail and web surfing. We constructed a design space for one-hand targeting interactions and proposed design considerations for onehand targeting in real mobile phone circumstances.

BackgroundThough cluster analysis has become a routine analytic task for bioinformatics research, it is still arduous for researchers to assess the quality of a clustering result. To select the best clustering method and its parameters for a dataset, researchers have to run multiple clustering algorithms and compare them. However, such a comparison task with multiple clustering results is cognitively demanding and laborious.ResultsIn this paper, we present XCluSim, a visual analytics tool that enables users to interactively compare multiple clustering results based on the Visual Information Seeking Mantra. We build a taxonomy for categorizing existing techniques of clustering results visualization in terms of the Gestalt principles of grouping. Using the taxonomy, we choose the most appropriate interactive visualizations for presenting individual clustering results from different types of clustering algorithms. The efficacy of XCluSim is shown through case studies with a bioinformatician.ConclusionsCompared to other relevant tools, XCluSim enables users to compare multiple clustering results in a more scalable manner. Moreover, XCluSim supports diverse clustering algorithms and dedicated visualizations and interactions for different types of clustering results, allowing more effective exploration of details on demand. Through case studies with a bioinformatics researcher, we received positive feedback on the functionalities of XCluSim, including its ability to help identify stably clustered items across multiple clustering results.

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The International Classification of Diseases (ICD)-10 code (U09.9) for post-acute sequelae of COVID-19 (PASC) was introduced in October of 2021. As researchers seek to leverage this billing code for research purposes in large scale real-world studies of PASC, it is of utmost importance to understand the functional use of the code by healthcare providers and the clinical characteristics of patients who have been assigned this code. To this end, we operationalized clinical case definitions of PASC using World Health Organization and Centers for Disease Control guidelines. We then chart reviewed 300 patients with COVID-19 from three participating healthcare systems of the 4CE Consortium who were assigned the U09.9 code. Chart review results showed the average positive predictive value (PPV) of the U09.9 code ranged from 40.2% to 65.4% depending on which definition of PASC was used in the evaluation. The PPV of the U09.9 code also fluctuated significantly between calendar time periods. We demonstrated the potential utility of textual data extracted from natural language processing techniques to more comprehensively capture symptoms associated with PASC from electronic health records data. Finally, we investigated the utilization of long COVID clinics in the cohort of patients. We observed that only an average of 24.0% of patients with the U09.9 code visited a long COVID clinic. Among patients who met the WHO PASC definition, only an average of 35.6% visited a long COVID clinic.

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